The saga of XMRV: a virus that infects human cells but is not a human virus

M Arias, H Fan - Emerging Microbes & Infections, 2014 - Taylor & Francis
Xenotropic murine leukemia virus-related virus (XMRV) was discovered in 2006 in a search
for a viral etiology of human prostate cancer (PC). Substantial interest in XMRV as a …

Recombinant origin, contamination, and de-discovery of XMRV

K Delviks-Frankenberry, O Cingöz, JM Coffin… - Current opinion in …, 2012 - Elsevier
The discovery and de-discovery of the xenotropic murine leukemia virus-related virus
(XMRV) has been a tumultuous roller-coaster ride for scientists and patients. The initial …

The tale of xenotropic murine leukemia virus-related virus

HCT Groom, KN Bishop - Journal of general virology, 2012 - microbiologyresearch.org
In 2006, a new retrovirus was isolated from prostate cancer patient tissue. Named xenotropic
murine leukemia virus-related virus (XMRV), this was potentially the third class of retrovirus …

In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer

D Lee, J Das Gupta, C Gaughan, I Steffen, N Tang… - 2012 - journals.plos.org
XMRV, or xenotropic murine leukemia virus (MLV)-related virus, is a novel gammaretrovirus
originally identified in studies that analyzed tissue from prostate cancer patients in 2006 and …

Xenotropic murine leukemia virus-related virus (XMRV) and the safety of the blood supply

AD Johnson, CS Cohn - Clinical microbiology reviews, 2016 - Am Soc Microbiol
In 2006, a new virus, xenotropic murine leukemia virus-related virus (XMRV), was
discovered in a cohort of US men with prostate cancer. Soon after this initial finding, XMRV …

Utilization of replication-competent XMRV reporter-viruses reveals severe viral restriction in primary human cells

CM Stürzel, D Palesch, M Khalid, S Wissing… - PLoS …, 2013 - journals.plos.org
The gammaretrovirus termed xenotropic murine leukemia virus-related virus (XMRV) was
described to be isolated from prostate cancer tissue biopsies and from blood of patients …

Disease-associated XMRV sequences are consistent with laboratory contamination

S Hué, ER Gray, A Gall, A Katzourakis, CP Tan… - Retrovirology, 2010 - Springer
Background Xenotropic murine leukaemia viruses (MLV-X) are endogenous
gammaretroviruses that infect cells from many species, including humans. Xenotropic …

No evidence of XMRV or MuLV sequences in prostate cancer, diffuse large Bcell lymphoma, or the UK blood donor population

MJ Robinson, PW Tuke, O Erlwein… - Advances in …, 2011 - Wiley Online Library
Xenotropic murine leukaemia virusrelated virus (XMRV) is a recently described retrovirus
which has been claimed to infect humans and cause associated pathology. Initially identified …

Of mice and men: on the origin of XMRV

AC Van Der Kuyl, M Cornelissen… - Frontiers in Microbiology, 2011 - frontiersin.org
The novel human retrovirus xenotropic murine leukemia virus-related virus (XMRV) is
arguably the most controversial virus of this moment. After its original discovery in prostate …

XMRV Discovery and Prostate CancerRelated Research

DE Kang, MC Lee, J Das Gupta, EA Klein… - Advances in …, 2011 - Wiley Online Library
Xenotropic murine leukemia virusrelated virus (XMRV) was first reported in 2006 in a study
of human prostate cancer patients with genetic variants of the antiviral enzyme, RNase L …