… associated with cancer development. The evidence for the involvement of these factors in …
Further, we examine the efforts to specifically target these transcription factors for therapeutic …

… can blunt the ability of the cancer therapy to induce cell death. Below, I … cancer and that its
inhibition is a logical therapy for certain cancers and for adjuvant approaches to cancer therapy…

… However, the full potential of transcription factors as novel targets for cancer therapy has
not been realized and many challenges remain, from the validation of novel targets to the …

… cancer therapies, as they show tumor-specific effects. In fact, the status of NR in cancer …
) currently being pursued as therapeutic targets in different types of cancer. We summarized …

… transcription factor will then trigger the death of the cancer cell. … suggest that therapies
targeting a transcription factor have … therapeutic index – a wide dosing window in which cancer …

… underlying such therapeutic modality for cancer therapy. … Two levels of therapeutic
intervention can be entertained, each … fusion transcription factors or the reversal of inappropriate …

… of transcription factors are overactive in most human cancer … and hopeful targets for treating
cancer is proposed, and this is … are oncogenic transcription factors. But how could specific …

… The link between NF-κB and cancer stems, in part, from the fact that this transcription factor
is capable of inducing gene products that control proliferative responses and that suppress …

… Transcription factor activity is often altered in human cancers … frequent target for therapeutic
interventions [5]. Whereas … Application of ZFPs in targeted cancer therapy has also been …

… to its DNA binding sequence in order to regulate physiological differentiation process
within the leukemic cells, as a first-in-class differentiation approach in cancer therapy [182,183,184]…