A complex task? Direct modulation of transcription factors with small molecules
AN Koehler - Current opinion in chemical biology, 2010 - Elsevier
… new transcription factor-based focus in medicine, especially with respect to cancer [2]. He
argued that selected transcription factors … that directly modulate transcription factors other than …
argued that selected transcription factors … that directly modulate transcription factors other than …
Identifying transcription factor complexes and their roles
T Will, V Helms - Bioinformatics, 2014 - academic.oup.com
… signals of many different factors. In particular, complexation of transcription factors (TFs) and
other … Common approaches for protein complex prediction that only use protein interaction …
other … Common approaches for protein complex prediction that only use protein interaction …
Sequence and chromatin determinants of transcription factor binding and the establishment of cell type-specific binding patterns
D Srivastava, S Mahony - Biochimica et Biophysica Acta (BBA)-Gene …, 2020 - Elsevier
… Transcription factors (TFs) selectively bind distinct sets of sites in different cell types. Such …
these studies are leading to a more complex and nuanced understanding of dynamic protein-…
these studies are leading to a more complex and nuanced understanding of dynamic protein-…
Human transcription factor protein interaction networks
H Göös, M Kinnunen, K Salokas, Z Tan, X Liu… - Nature …, 2022 - nature.com
… To assess how the studied TFs interacted with PIC components, we retrieved GTFs and
Mediator complex members from the CORUM protein complex database and compared them to …
Mediator complex members from the CORUM protein complex database and compared them to …
Transcription factor dynamics
… complexes … complexes without assumption of their assembly mechanism or function. In
parallel, live-cell mRNA imaging experiments have similarly uncovered complex transcription …
parallel, live-cell mRNA imaging experiments have similarly uncovered complex transcription …
Transcription factors: Time to deliver
… Transcription factors are key regulatory molecules involved in this regulation, scanning the
genome and modulating gene activity via binding specific elements [2], [3]. TFs represent a …
genome and modulating gene activity via binding specific elements [2], [3]. TFs represent a …
Transcription factor drug targets
KA Papavassiliou… - Journal of cellular …, 2016 - Wiley Online Library
… transcription factors in human diseases and we discuss emerging pharmacological strategies
to modulate transcription factor … part of complex and dynamic transcription factor networks. …
to modulate transcription factor … part of complex and dynamic transcription factor networks. …
Functional versatility of transcription factors in the nervous system: the SRF paradigm
B Knöll, A Nordheim - Trends in neurosciences, 2009 - cell.com
… transcription factor CREB and point out overlapping, distinct and concerted functions of these
two transcriptional … The best studied SRF partner proteins are the ternary complex factors (…
two transcriptional … The best studied SRF partner proteins are the ternary complex factors (…
Plant transcription factors: present knowledge and future challenges
F Katagiri, NH Chua - Trends in Genetics, 1992 - cell.com
… is responsible for a function), more complex gene regulatory systems must exist. Evidence
is accumulating that selective gene expression in plants can be brought about by synergistic …
is accumulating that selective gene expression in plants can be brought about by synergistic …
Orchestrated response: a symphony of transcription factors for gene control
B Lemon, R Tjian - Genes & development, 2000 - genesdev.cshlp.org
… One possible advantage to a holo-complex is the ability to obviate the limited cellular
concentration of individual transcription factors. A pre-assembled RNA polymerase complex could, …
concentration of individual transcription factors. A pre-assembled RNA polymerase complex could, …
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- plant transcription factors
- human transcription factors
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- transcription factor sequence and chromatin determinants
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- transcription factor complexes distinct chromatin
- transcription factors in saccharomyces cerevisiae
- transcription factor sensitivity
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- transcription factor cooperativity
- transcription factor binding kinetics
- transcription factor properties