A complex task? Direct modulation of transcription factors with small molecules

AN Koehler - Current opinion in chemical biology, 2010 - Elsevier
… new transcription factor-based focus in medicine, especially with respect to cancer [2]. He
argued that selected transcription factors … that directly modulate transcription factors other than …

Identifying transcription factor complexes and their roles

T Will, V Helms - Bioinformatics, 2014 - academic.oup.com
… signals of many different factors. In particular, complexation of transcription factors (TFs) and
other … Common approaches for protein complex prediction that only use protein interaction …

Sequence and chromatin determinants of transcription factor binding and the establishment of cell type-specific binding patterns

D Srivastava, S Mahony - Biochimica et Biophysica Acta (BBA)-Gene …, 2020 - Elsevier
Transcription factors (TFs) selectively bind distinct sets of sites in different cell types. Such …
these studies are leading to a more complex and nuanced understanding of dynamic protein-…

Human transcription factor protein interaction networks

H Göös, M Kinnunen, K Salokas, Z Tan, X Liu… - Nature …, 2022 - nature.com
… To assess how the studied TFs interacted with PIC components, we retrieved GTFs and
Mediator complex members from the CORUM protein complex database and compared them to …

Transcription factor dynamics

F Lu, T Lionnet - Cold Spring Harbor Perspectives in …, 2021 - cshperspectives.cshlp.org
complexescomplexes without assumption of their assembly mechanism or function. In
parallel, live-cell mRNA imaging experiments have similarly uncovered complex transcription

Transcription factors: Time to deliver

AV Ulasov, AA Rosenkranz, AS Sobolev - Journal of Controlled Release, 2018 - Elsevier
Transcription factors are key regulatory molecules involved in this regulation, scanning the
genome and modulating gene activity via binding specific elements [2], [3]. TFs represent a …

Transcription factor drug targets

KA Papavassiliou… - Journal of cellular …, 2016 - Wiley Online Library
transcription factors in human diseases and we discuss emerging pharmacological strategies
to modulate transcription factor … part of complex and dynamic transcription factor networks. …

Functional versatility of transcription factors in the nervous system: the SRF paradigm

B Knöll, A Nordheim - Trends in neurosciences, 2009 - cell.com
transcription factor CREB and point out overlapping, distinct and concerted functions of these
two transcriptional … The best studied SRF partner proteins are the ternary complex factors (…

Plant transcription factors: present knowledge and future challenges

F Katagiri, NH Chua - Trends in Genetics, 1992 - cell.com
… is responsible for a function), more complex gene regulatory systems must exist. Evidence
is accumulating that selective gene expression in plants can be brought about by synergistic …

Orchestrated response: a symphony of transcription factors for gene control

B Lemon, R Tjian - Genes & development, 2000 - genesdev.cshlp.org
… One possible advantage to a holo-complex is the ability to obviate the limited cellular
concentration of individual transcription factors. A pre-assembled RNA polymerase complex could, …