Docosahexaenoic acid regulates the formation of lipid rafts: A unified view from experiment and simulation

SR Wassall, X Leng, SW Canner… - … et Biophysica Acta (BBA …, 2018 - Elsevier
lipid rafts on the nanometer and micrometer size scales. The applied methods ranged from
MD simulation … of PC promote phase separation and enhance raft size. The rationale for using …

Assessing the nature of lipid raft membranes

PS Niemelä, S Ollila, MT Hyvönen… - PLoS computational …, 2007 - journals.plos.org
experiments. In this work, we employ extensive atom-scale simulations to elucidate the
properties of ternary raft … We simulate two bilayers of 1,024 lipids for 100 ns in the liquid-ordered …

Structure of cholesterol in lipid rafts

L Toppozini, S Meinhardt, CL Armstrong, Z Yamani… - Physical review …, 2014 - APS
simulations is around 20σ, corresponding to 10–20 nanometers. Both simulations and
experiments … lo-type regions containing both lipids and cholesterol, and cholesterol plaques. The …

The molecular face of lipid rafts in model membranes

HJ Risselada, SJ Marrink - Proceedings of the National …, 2008 - National Acad Sciences
… that has thus far eluded experimental determination. We are able to … simulations such as
presented in the current work will hopefully aid in our understanding of the nature of lipid rafts

Lipid rafts: buffers of cell membrane physical properties

JD Nickels, MD Smith, RJ Alsop… - The Journal of …, 2019 - ACS Publications
… Our experimental observations and MD simulations of a simple model membrane … (16) The
purely physical advantage of lipid rafts might be envisioned at the ancient origins of lipid rafts, …

[HTML][HTML] Computer simulations of lipid membrane domains

WFD Bennett, DP Tieleman - Biochimica et Biophysica Acta (BBA) …, 2013 - Elsevier
… where simulations are used in collaboration with experiments. We review recent simulation
studies on lipidlipid … formation and on lipid–protein interactions relevant for lipid raft function. …

Optimization of hydrophobic nanoparticles to better target lipid rafts with molecular dynamics simulations

X Lin, X Lin, N Gu - Nanoscale, 2020 - pubs.rsc.org
… insights into the experimental design of functional nanoparticles, targeting the lipid raft and
… dynamics of NPs between raft and non-raft membrane domains in our simulations. It is worth …

Partitioning, diffusion, and ligand binding of raft lipid analogs in model and cellular plasma membranes

E Sezgin, I Levantal, G Schwarzmann, V Mueller… - Biophysical …, 2012 - cell.com
… the ones seen in experiments. The obtained configurations … DHA can differentially disrupt
lipid raft molecular organization, … We perform Monte Carlo simulations of bimFCS experiments …

Studying the role of lipid rafts on protein receptor bindings with cellular automata

F Haack, K Burrage, R Redmer… - … /ACM transactions on …, 2013 - ieeexplore.ieee.org
… Please note our first experiments in Section 3.1 focus on the upper part (the dynamics …
simulation tool for Lipid Rafts Models—that allows pathway-specific simulation studies of lipid rafts

Why are lipid rafts not observed in vivo?

A Yethiraj, JC Weisshaar - Biophysical journal, 2007 - cell.com
… Using computer simulations of a lattice model of the membrane, we show that the presence
… Because we fit ɛ to experiment, in the absence of obstacles, the type of lattice will merely …