… fatty acids comprising the membrane hydrophobic core [6]. We believe that this unusual fatty
acid, … , shorter and less unsaturated membrane fatty acids, will nevertheless alter membrane …

… fatty acid synthesis, enclosed by boxes, are formed at the subunit interface through cooperation
between the three N-terminal domains of one subunit and the four C-terminal domains of …

… The positioning of domains reveals the complex architecture of the multienzyme forming an
… a full set of catalytic domains required for fatty acid elongation. Large distances between …

… We investigated the phase behavior of lipid membranes containing fatty acids (FAs) by
microscopy and differential scanning calorimetry. We used palmitic acid (saturated FA), oleic acid …

… We show here that the fatty acid synthase activity could not … are essential for fatty acid
synthase dimer formation. Further, … their domains are indicated in the subunits of FAS. The dimer …

… the fatty acid synthases (FASs) have evolved into large multifunctional enzymes that integrate
the whole process of fatty acid … (a) The β-chain is formed by consecutive globular domains, …

… leads to the rupture of some and the formation of other interhelical interactions. The ion
pair … This is compensated by the formation of new nonbonded contacts such as that formed …

… by a single bifunctional protein domain, the malonyl-acetyl … ACP as free fatty acids by a
thioesterase (TE) domain (6). … formed by the linkers flanking the KR and ΨKR domains are …

… polymeric gegenion, the phase behavior of several longchain fatty acids 2 at the air/water
interface could be influenced distinctly. Their domain formation in the coexistence region could …

… (ER) leading to the formation of a saturated four-carbon fatty acid attached to ACP. KS mediates
… synthesis, stoichiometric amounts of interdomain containing domain I and domain II-III …