… of the amyloid hypothesis of Alzheimer’s disease is that the deposition of amyloid-β precedes
… To investigate the temporal relation between plaque formation and the changes in local …

… In light of these circumstances, alternative strategies to reduce Aβ aggregation and toxicity
… a completely random coil by the presence of local, nonrandom conformations (15). Trends …

Background: In Alzheimer’s disease (AD), amyloid-β (Aβ) is the major component of extracellular
plaques, whereas the microtubule-associated protein tau forms the main component of …

… of amyloid-β (Aβ) species. Aβ peptides can transform structurally from monomers into β-…
Among the various Aβ species, structured oligomers are proposed to be more toxic than …

… A review of the multidisciplinary scientific literature reveals a large variety of amyloid-β (Aβ) …
between the different Aβ species and their toxicity is currently dictating the nature of the …

… in relation to the current literature on toxicity, inflammation, and immunotherapy with a focus
on Aβ but extending to other amyloid oligomers where the mechanisms seem universal. We …

… To determine the role that local surface structures play in Aβ toxicity, we assessed the β-aggregation
capacity and cytotoxicity of two mutant Aβ peptides. One mutant, (Ala) 3 , is a point …

… Aβ by locally concentrating Aβ molecules but also generate … a major component of which is
the fibrillar amyloid β-protein (Aβ). It is … -spanning amyloid precursor protein (APP) by β- and γ-…

… The discovery of amyloid deposits in brains of patients with Alzheimer's disease (AD) … link
between aberrant amyloid beta protein (Aβ) accumulation and local tissue toxicity. Aβ is formed …

… Since the reformulation of the amyloid cascade hypothesis to focus on oligomeric aggregates
of amyloid beta as the prime toxic species causing Alzheimer's disease, many researchers …