… amyloid imaging agent, methoxy-XO4, would not report amyloid-β deposits that do not
contain β-pleated sheets, we compared immunostaining for amyloid-β and methoxy-XO4 in …

… In separate experiments, PIB-labeled amyloid-β deposits were detectable up to 3 days after
a single … This graph illustrates the rapid appearance of fluorescent dye in blood vessels, the …

… To provide further evidence for the rapid formation of amyloid-β 1–40 oligomers, we
recorded dynamic light scattering time courses (Fig. 3a). We incubated monomerized CC-…

… Recent studies suggest that soluble intermediates formed during amyloid β-protein (Aβ) …
Neurons exposed to Arctic Aβ showed a progressive degeneration that was much more rapid …

… of insoluble fibrillar amyloid aggregates in the brain parenchyma and cerebral vessels (see
ref 1). The primary component of these amyloid deposits is the amyloid-β peptide (Aβ). Aβ is …

… conversion to a predominant β-structured conformation in 2 mM SDS which does not
proceed to amyloid fibrils. The conformational change is instead rapidly followed by the near …

… Nonfibrillar, water-soluble low-molecular weight assemblies of the amyloid β-protein (Aβ) …
more rapidly than either AβS26C or wild-type monomers and formed parastable β-sheet rich…

… first applied to the P-amyloid QLS is an optical technique for the rapid, non-invasive,
quantitative … upon peptide dissolution and the rapid polymerization of AD made determination of …

… [104] and is surprisingly rapid in that system and includes vascular amyloid [105]. Although
this … Not all pools of Aβ in the human brain may participate in this rapid exchange of monomer …

… The primary goal of the study was to establish conformational structural characteristics of
amyloid-β in neuropathologically verified rapidly and slowly progressive Alzheimer’s disease …