The mucosal immune system: master regulator of bidirectional gut–brain communications

N Powell, MM Walker, NJ Talley - Nature reviews Gastroenterology & …, 2017 - nature.com
Communication between the brain and gut is not one-way, but a bidirectional highway
whereby reciprocal signals between the two organ systems are exchanged to coordinate …

Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium

KA Sharkey, PL Beck, DM McKay - Nature reviews Gastroenterology & …, 2018 - nature.com
The epithelial lining of the gastrointestinal tract serves as the interface for digestion and
absorption of nutrients and water and as a defensive barrier. The defensive functions of the …

The brain-gut axis in health and disease

Y Al Omran, Q Aziz - Microbial endocrinology: the microbiota-gut-brain …, 2014 - Springer
The interaction between the brain and the gut has been recognized for many centuries. This
bidirectional interaction occurs via neural, immunological and hormonal routes, and is …

Microbes and the gut‐brain axis

P Bercik, SM Collins, EF Verdu - Neurogastroenterology & …, 2012 - Wiley Online Library
Background The 'gut‐brain'or 'brain‐gut axis', depending on whether we emphasize bottom‐
up or top‐bottom pathways, is a bi‐directional communication system, comprised of neural …

[HTML][HTML] Brain–gut–microbe communication in health and disease

S Grenham, G Clarke, JF Cryan, TG Dinan - Frontiers in physiology, 2011 - frontiersin.org
Bidirectional signalling between the gastrointestinal tract and the brain is regulated at
neural, hormonal, and immunological levels. This construct is known as the brain–gut axis …

The joint power of sex and stress to modulate brain–gut–microbiota axis and intestinal barrier homeostasis: implications for irritable bowel syndrome

M Pigrau, BK Rodiño‐Janeiro… - …, 2016 - Wiley Online Library
Background Intestinal homeostasis is a dynamic process that takes place at the interface
between the lumen and the mucosa of the gastrointestinal tract, where a constant scrutiny for …

The Brain-Gut-Microbiotal Axis: A framework for understanding functional GI illness and their therapeutic interventions

C Tait, GS Sayuk - European Journal of Internal Medicine, 2021 - Elsevier
Functional gastrointestinal disorders (FGIDs), characterized by chronic abdominal
complaints without a structural or biochemical cause, are common diseases that are …

[HTML][HTML] The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes

A Jacobson, D Yang, M Vella, IM Chiu - Mucosal immunology, 2021 - Elsevier
The gastrointestinal tract is densely innervated by a complex network of neurons that
coordinate critical physiological functions. Here, we summarize recent studies investigating …

[HTML][HTML] The microbiota-immune axis as a central mediator of gut-brain communication

TC Fung - Neurobiology of disease, 2020 - Elsevier
Intestinal inflammatory disorders are associated with neurophysiological and behavioral
symptoms. Conversely, many disorders of the central nervous system (CNS) are …

The gut–brain axis in health neuroscience: implications for functional gastrointestinal disorders and appetite regulation

N Weltens, J Iven, L Van Oudenhove… - Annals of the New York …, 2018 - Wiley Online Library
Over the past few years, scientific interest in the gut–brain axis (ie, the bidirectional
communication system between the gastrointestinal tract and the brain) has exploded …