Tubulointerstitial fibrosis (TIF) is the hallmark of chronic kidney disease and best predictor of
renal survival. Many different cell types contribute to TIF progression including tubular …

Renal fibrosis is the common end point of virtually all progressive kidney diseases. Renal
fibrosis should not be viewed as a simple and uniform'scar', but rather as a dynamic system …

The pathologic paradigm for renal progression is advancing tubulointerstitial fibrosis.
Whereas mechanisms underlying fibrogenesis have grown in scope and understanding in …

Tubulointerstitial fibrosis is a chronic and progressive process affecting kidneys during aging
and in chronic kidney disease (CKD), regardless of cause. CKD and renal fibrosis affect half …

Renal interstitial fibrosis: mechanisms and evaluation : Current Opinion in Nephrology and
Hypertension Renal interstitial fibrosis: mechanisms and evaluation : Current Opinion in …

Tubuloinferstitial fibrosis is a final common pathway for progressive renal injury in
most'inflammatory'and'non-inflammatory'glomerulopathies. Indeed, the level of …

Tubular injury has a major etiological role in fibrosis. For many years, this relationship has
been dominated by the perception that epithelial cells are transformed into myofibroblasts …

Progressive interstitial fibrosis accompanied by loss of renal tubules and interstitial
capillaries typifies all progressive renal diseases. Dynamic and complex, the process …

The progression of chronic renal failure is characterised histologically by
glomerulosclerosis, tubulointerstitial fibrosis and vascular sclerosis. Recent research has …

Mechanisms do, however, exist within the tubulointerstium that promote tubulointerstitial
injury [5–9], a view strengthened by Johnson et al [4]. Interstitial fibrosis independently …