The prospect of FKBP51 as a drug target
MV Schmidt, M Paez‐Pereda, F Holsboer… - …, 2012 - Wiley Online Library
The FK506 binding protein 51 (FKBP51) is best known as an Hsp90‐associated co‐
chaperone that regulates the responsiveness of steroid hormone receptors. In human …
chaperone that regulates the responsiveness of steroid hormone receptors. In human …
[HTML][HTML] The many faces of FKBP51
The FK506-binding protein 51 (FKBP51) has emerged as a key regulator of endocrine stress
responses in mammals and as a potential therapeutic target for stress-related disorders …
responses in mammals and as a potential therapeutic target for stress-related disorders …
Recent progress in FKBP ligand development
FK506-binding proteins have been implicated in numerous human diseases suggesting
novel therapeutic opportunities. In particular, the large FKBP51 has emerged as an …
novel therapeutic opportunities. In particular, the large FKBP51 has emerged as an …
The FKBP51-glucocorticoid receptor balance in stress-related mental disorders
The immunophilin FK506 binding protein 51 (FKBP51) has emerged as one of the most
intensely investigated proteins in stress-related mental disorders. It was originally …
intensely investigated proteins in stress-related mental disorders. It was originally …
Rapid, structure-based exploration of pipecolic acid amides as novel selective antagonists of the FK506-binding protein 51
S Gaali, X Feng, A Hähle, C Sippel… - Journal of medicinal …, 2016 - ACS Publications
The FK506-binding protein 51 (FKBP51) is a key regulator of stress hormone receptors and
an established risk factor for stress-related disorders. Drug development for FKBP51 has …
an established risk factor for stress-related disorders. Drug development for FKBP51 has …
Selective inhibitors of the FK506-binding protein 51 by induced fit
S Gaali, A Kirschner, S Cuboni, J Hartmann… - Nature chemical …, 2015 - nature.com
Abstract The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an
established risk factor for stress-related psychiatric disorders such as major depression …
established risk factor for stress-related psychiatric disorders such as major depression …
[HTML][HTML] Focus on FKBP51: A molecular link between stress and metabolic disorders
Abstract Background Obesity, Type 2 diabetes (T2D) as well as stress-related disorders are
rising public health threats and major burdens for modern society. Chronic stress and …
rising public health threats and major burdens for modern society. Chronic stress and …
Hsp90 and FKBP51: complex regulators of psychiatric diseases
M Criado-Marrero, T Rein… - … of the Royal …, 2018 - royalsocietypublishing.org
Mood disorders affect nearly a quarter of the world's population. Therefore, understanding
the molecular mechanisms underlying these conditions is of great importance. FK-506 …
the molecular mechanisms underlying these conditions is of great importance. FK-506 …
Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52)
The large FK506-binding protein FKBP52 has been characterized as an important positive
regulator of androgen, glucocorticoid and progesterone receptor signaling pathways …
regulator of androgen, glucocorticoid and progesterone receptor signaling pathways …
[HTML][HTML] The FKBP51 glucocorticoid receptor co-chaperone: regulation, function, and implications in health and disease
Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR),
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …