[HTML][HTML] Saline nasal irrigation and gargling in COVID-19: a multidisciplinary review of effects on viral load, mucosal dynamics, and patient outcomes

S Huijghebaert, S Parviz, D Rabago, A Baxter… - Frontiers in Public …, 2023 - frontiersin.org
With unrelenting SARS-CoV-2 variants, additional COVID-19 mitigation strategies are
needed. Oral and nasal saline irrigation (SI) is a traditional approach for respiratory …

[HTML][HTML] Hypertonic saline nasal irrigation and gargling should be considered as a treatment option for COVID-19

S Ramalingam, C Graham, J Dove, L Morrice… - Journal of global …, 2020 - ncbi.nlm.nih.gov
Post-hoc analysis of a pilot randomised controlled trial of hypertonic saline nasal irrigation
and gargling in adults with upper respiratory tract infection found that in a subgroup with …

[PDF][PDF] Hypertonic saline nasal irrigation and gargling as an inexpensive practical adjunctive weapon to combat asymptomatic SARS-CoV-2 infections

P Rosati, U Giordano, C Concato - Trends in Medicine, 2020 - researchgate.net
Background In vitro, irrefutable biochemical evidence shows that chloride (Cl-) ions,
converted into hypochlorous acid (HOCl), are an innate human immune mechanism …

Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients

AL Baxter, KR Schwartz, RW Johnson… - Ear, Nose & Throat …, 2022 - journals.sagepub.com
Objective To determine whether initiating saline nasal irrigation after COVID-19 diagnosis
reduces hospitalization and death in high-risk outpatients compared with observational …

Do saline water gargling and nasal irrigation confer protection against COVID-19?

P Panta, K Chatti, A Andhavarapu - Explore, 2021 - Elsevier
This report provides a perspective on the relevance of saline water gargling and nasal
irrigation to the COVID-19 crisis. While there is limited evidence concerning their curative or …

[HTML][HTML] Interim analysis of an open-label randomized controlled trial evaluating nasal irrigations in non-hospitalized patients with COVID-19

KS Kimura, MH Freeman, BC Wessinger… - International forum of …, 2020 - ncbi.nlm.nih.gov
Methods We identified patients diagnosed with a positive qualitative RT-PCR SARS-CoV-2
diagnostic test obtained from Vanderbilt University Medical Center and affiliated testing …

[HTML][HTML] The effect of isotonic saline nasal lavages in improving symptoms in SARS-CoV-2 infection: a case-control study

G Spinato, C Fabbris, G Costantini, F Conte… - Frontiers in …, 2021 - frontiersin.org
Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mainly
colonizes nasopharynx. In upper airways acute infections, eg, the common cold, saline …

[HTML][HTML] Rapid initiation of nasal saline irrigation: hospitalizations in COVID-19 patients randomized to alkalinization or povidone-iodine compared to a national …

AL Baxter, KR Schwartz, RW Johnson, ASRS Rao… - MedRxiv, 2021 - medrxiv.org
Objective To determine whether nasal irrigation initiated within 24 hours of a positive PCR
test result reduces hospitalizations for COVID-19. Design, Setting and Participants …

[HTML][HTML] Efficacy of normal saline nasal spray and gargle on SARS-CoV-2 for prevention of COVID-19 pneumonia

U Chatterjee, A Chakraborty, S Naskar, B Saha… - 2021 - europepmc.org
Background: Role of microaspiration of mucus mixed with SARS-CoV-2 (severe acute
respiratory syndrome corona virus 2) causing pneumonia is lacking in searched literature …

[HTML][HTML] Essentials in saline pharmacology for nasal or respiratory hygiene in times of COVID-19

S Huijghebaert, L Hoste, G Vanham - European journal of clinical …, 2021 - Springer
Purpose Nasal irrigation or nebulizing aerosol of isotonic or hypertonic saline is a traditional
method for respiratory or nasal care. A recent small study in outpatients with COVID-19 …