Simple Summary The development of uveal melanoma is a multifactorial and multi-step
process, in which specific and recurrent mutations arise early. Among the recurrently …

The recent identification of frequent activating mutations in GNAQ or GNA11 in uveal
melanoma provides an opportunity to better understand the pathogenesis of this melanoma …

Background: Mutations in GNAQ and GNA11, encoding the oncogenic G-protein alpha
subunit q and 11, respectively, occur frequently in the majority of uveal melanomas …

Uveal melanoma is the most common malignant tumor of the adult eye. Fifty percent of
tumors will eventually metastasize, and there are no effective treatments for them. Recent …

Background Uveal melanoma is the most common intraocular cancer. There are no effective
therapies for metastatic disease. Mutations in GNAQ, the gene encoding an alpha subunit of …

Uveal melanoma is the most common primary intraocular malignant tumor in adults and
arises from the transformation of melanocytes in the uveal tract. Even after treatment of the …

Background and aim of the study Mutations in the Gα-genes GNAQ and GNA11 are found in
85–90% of uveal melanomas (UM). Aim of the study is to understand whether the mutations …

Uveal melanoma (UM) represents the most prominent primary eye cancer in adults. With an
incidence of approximately 5 cases per million individuals annually in the United States, UM …

Uveal melanoma (UM) is a genetically and biologically distinct type of melanoma, and once
metastatic there is no effective treatment currently available. Eighty percent of UMs harbor …

GNAQ and GNA11 are heterotrimeric G protein alpha subunits, which are mutated in a
mutually exclusive pattern in most cases of uveal melanoma, one of the most aggressive …