The genotoxicity of the most potent carcinogen in cigarette smoke [4-(methylnitrosamino)-1-
(3-pyridyl)-1-butanone (NNK)] is dependent on the relationship between its activation by …

The tobacco specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK),
which is found in high amounts in tobacco products, is believed to play an important role in …

This article reviews recent advances in the biochemistry and molecular biology of 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific pulmonary car …

The balance between metabolic activation and detoxification is critical in determining the
susceptibility to lung cancer upon exposure to the tobacco specific nitrosamine, 4 …

We have developed a human B-lymphoblastoid cell line, designated 2D6/Hol, which stably
expresses human cyto chrome P450 CYP2D6 cDNA. This cell line exhibits bufuralol 11 …

(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a potent tobacco-specific carcinogen in
animals, has been linked to tobacco-related cancers in humans. The cytochrome (s) P-450 …

Abstract The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK) is a potent pulmonary carcinogen in laboratory animals and is most likely involved in …

In a “landmark interview” on the subject of the Millers' seminal paper on the presence of
bound aminoazo dyes in the livers of rats fed p-dimethylaminoazobenzene, James A. Miller …

(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent lung carcinogen present in
both unburned tobacco and cigarette smoke. The sum of 4-(methylnitrosamino)-1-(3-pyridyl) …

Tobacco use continues to be a major cause of cancer in the developed world, and despite
significant progress in this country in tobacco control, which is driving a decrease in cancer …