Representing the major cause of morbidity and mortality for chronic lymphocytic leukemia
(CLL) patients, immunosuppression is a common feature of the disease. Effectors of the …

Intrinsic factors such as genetic lesions, anti-apoptotic proteins, and aberrant signaling
networks within leukemia cells have long been the main focus of chronic lymphocytic …

In chronic lymphocytic leukemia (CLL), B-cell receptor signaling, tumor–microenvironment
interactions, and somatic mutations drive disease progression. To better understand the …

Over the past decade, the introduction of nucleoside analogs and monoclonal antibodies
into the treatment of patients with chronic lymphocytic leukemia (CLL) has resulted in higher …

Biology of Chronic Lymphocytic Leukemia in Different Microenvironments - Hematology/Oncology
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Chronic lymphocytic leukemia (CLL) cells survive longer in vivo than in vitro, suggesting that
the tissue microenvironment provides prosurvival signals to tumor cells. Primary and …

The tumor microenvironment (TME) plays an essential role in the development, growth, and
survival of the malignant B-cell clone in chronic lymphocytic leukemia (CLL). Within the …

Chronic lymphocytic leukemia (CLL) is a malignancy of mature, antigen-experienced B
lymphocytes. Despite great progress recently achieved in the management of CLL, the …

Abstract Chronic Lymphocytic Leukemia (CLL) is a malignancy of mature B lymphocytes
which are highly dependent on interactions with the tissue microenvironment for their …

Chronic lymphocytic leukemia (CLL), an incurable malignancy of mature B lymphocytes,
involves blood, bone marrow, and secondary lymphoid organs such as the lymph nodes …