Cardiovascular diseases (CVDs) account for over 17 million death globally each year,
including arterial thrombosis. Platelets are key components in the pathogenesis of this …

Cyclooxygenase enzymes have distinct roles in cardiovascular, neurological, and
neurodegenerative disease. They are differently expressed in different type of cancers …

This paper focuses on the synthesis and the in vitro testing of dual COX-1/COX-2 inhibitors.
Starting from structures of non-steroidal anti-inflammatory drugs (NSAIDs) the diaryl …

A new class of selective cyclooxygenase-2 (COX-2) inhibitors has been identified by high
throughput screening. Structurally distinct from previously described selective COX-2 …

Abstract Selective cyclooxygenase (COX)‐1 inhibitors can be employed as potential
cardioprotective drugs. Moreover, COX‐1 plays a key role in inflammatory processes and its …

Several heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)
amine COX-2 inhibitors, in which the cyclopentene moiety was replaced by pyrazole …

The design of selective COX-2 inhibitors is a new approach to obtain potent, anti-
inflammatory drugs but with less side effects. Several families of such inhibitors were …

Three novel series of diaryl heterocyclic derivatives bearing the 2-oxo-5H-furan, 2-oxo-3H-1,
3-oxazole, and 1H-pyrazole moieties as the central heterocyclic ring were synthesized and …

Since cyclooxygenase (COX) isozymes discovery, many papers and reviews have been
published to describe the structural bases of COX inhibition, and to debate on the …

A group of (E)-and (Z)-1, 2, 3-triaryl-2-propen-1-one derivatives possessing a methylsulfonyl
COX-2 pharmacophore at the para position of the C-1 phenyl ring were synthesized and …