JAK2 inhibitors improve RA combined with pulmonary fibrosis in rats by downregulating SMAD3 phosphorylation

Y Wei, D Wang, J Wu, J Zhang - International Journal of …, 2024 - Wiley Online Library
Background JAK inhibitors are well known for the treatment of rheumatoid arthritis (RA), but
whether they can be used to treat pulmonary fibrosis, a common extra‐articular disease of …

Baricitinib improves pulmonary fibrosis in mice with rheumatoid arthritis-associated interstitial lung disease by inhibiting the Jak2/Stat3 signaling pathway

H Liu, Y Yang, J Zhang, X Li - Advances in Rheumatology, 2023 - SciELO Brasil
Objective The study explored improvements in pulmonary inflammation and fibrosis in a
bovine type II collagen-induced rheumatoid arthritis-associated interstitial lung disease …

Piceatannol-mediated JAK2/STAT3 signaling pathway inhibition contributes to the alleviation of oxidative injury and collagen synthesis during pulmonary fibrosis

Z Tieyuan, Z Ying, Z Xinghua, W Huimin… - International …, 2022 - Elsevier
Pulmonary fibrosis (PF) is characterized by oxidative injury and excessive collagen
synthesis in lung fibroblasts, causing impaired pulmonary function and chronic lung injury …

OP0216 Resveratrol ameliorates pulmonary fibrosis and inhibits human lung fibroblasts activation VIA modulating SIRT1 and GLI1 signaling

L Haobo, Z Guangfeng, Z Xiao - 2015 - ard.bmj.com
Background Connective tissue disease associated pulmonary fibrosis is a severe clinical
application with poor prognosis, myofibroblasts which mostly evolved from lung fibroblasts …

[HTML][HTML] Crosstalk between the JAK2 and TGF-β1 signaling pathways in scleroderma-related interstitial lung disease targeted by baricitinib

D Wang, Y Wei, L Xu, J Zhang - Advances in Rheumatology, 2023 - SciELO Brasil
Background and objective Systemic sclerosis (SSc) is an immune-mediated rheumatic
disease characterized by fibrosis and vascular lesions. Interstitial lung disease is an early …

POS0628 BARICITINIB AMELIORATES BLEOMYCIN-INDUCED PULMONARY AND SKIN FIBROSIS VIA JAK 1/2 INHIBITON

S Gulle, A Çelik, B Lebe, Ç Ulukuş, M Bariş… - 2023 - ard.bmj.com
Background Signal transducer and activator of transcription 3 (STAT3) protein is activated in
lung fibroblasts and alveolar type II cells (AT-II) and is thought to contribute to fibrosis in lung …

Canonical and noncanonical regulatory roles for JAK2 in the pathogenesis of rheumatoid arthritis‐associated interstitial lung disease and idiopathic pulmonary …

S Wang, M Liu, X Li, J Zhang, F Wang… - The FASEB …, 2022 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) and rheumatoid arthritis‐associated interstitial lung
disease (RA‐ILD) are two fibrotic interstitial lung diseases that share the usual interstitial …

Inhibitory effects of pirfenidone on fibroblast to myofibroblast transition in rheumatoid arthritis-associated interstitial lung disease via the downregulation of activating …

C Wu, H Lin, X Zhang - International Immunopharmacology, 2019 - Elsevier
Objective Pirfenidone (PFD) is an oral anti-fibrotic drug used for idiopathic pulmonary
fibrosis (IPF) therapy. We determined the role of activating transcription factor 3 (ATF3) and …

Resveratrol attenuates inflammation and fibrosis in rheumatoid arthritis-associated interstitial lung disease via the AKT/TMEM175 pathway

N Liu, X Fan, Y Shao, S Chen, T Wang, T Yao… - Journal of Translational …, 2024 - Springer
Background and purpose Interstitial lung disease (ILD) represents a significant complication
of rheumatoid arthritis (RA) that lacks effective treatment options. This study aimed to …

[HTML][HTML] Inhibition of the TGF-β/Smads signaling pathway attenuates pulmonary fibrosis and induces anti-proliferative effect on synovial fibroblasts in rheumatoid …

S Wang, S Wang, H Li, L Zhu… - International Journal of …, 2019 - ncbi.nlm.nih.gov
We explored whether transforming growth factor (TGF-β)/Smads signaling pathway
influences rheumatoid arthritis (RA)-associated pulmonary fibrosis (PF) and proliferation of …