Topical therapy of antifungals is primarily restricted due to the low innate transport of drugs
through the thick multi-layered keratinized nail plate. The objective of this investigation was …

The application of iontophoresis was demonstrated in the nail drug delivery of terbinafine
(TH) recently. This study explored a systematic assessment of this approach to enhance the …

Trans-nail permeability is limited due to the innate nature of the nail plate and the recent
investigations indicated the potential of iontophoresis in enhancing the transungual drug …

Purpose An ex vivo intact toe model was developed to assess two different applicator
designs for iontophoretic delivery of terbinafine into the nail only or the nail and surrounding …

Background Onychomycosis is a common disease. Topical treatment is usually not effective
due to limitation of trans-nail delivery of antifungal drugs. Successful treatment of deep …

Treatment of nail diseases by topical drug delivery continues to draw much attention in the
recent days. This study aims to systematically investigate the effect of constant voltage …

The efficacy of topical antifungal therapy in onychomycosis has been hindered by the failure
of the antimycotic to permeate the nail plate. This research aims to design and develop a …

Topical nail drug delivery could be improved by identifying potent chemical penetration
enhancers. The purpose of this study was to assess the effect of polyethylene glycols (PEGs) …

In present studies, a hyponychium pathway (from ventral side of the nail plate) was
investigated as a potential route of drug delivery into the nail apparatus using iontophoresis …

Objectives The poor success rate of topical therapy in nail disorders is mainly because of the
low permeability of keratinized nail plates. This can be overcome by utilizing potent …