The relevance of neuronal substrates of defense in the midbrain tectum to anxiety and stress: empirical and conceptual considerations

ML Brandão, AC Troncoso, MA de Souza Silva… - European journal of …, 2003 - Elsevier
The medial hypothalamus, amygdala, and dorsal periaqueductal gray constitute the main
neural substrates for the integration of aversive states in the brain. More recently, some …

Electrical stimulation of the midbrain tectum enhances dopamine release in the frontal cortex

G Cuadra, A Zurita, CE Macedo, VA Molina… - Brain Research …, 2000 - Elsevier
One widely used animal model of anxiety is the electrical stimulation of a given structure
supposed to be involved in the neural circuitry underlying emotional behavior. Indeed …

Neurochemical mechanisms of the defensive behavior in the dorsal midbrain

ML Brandão, VZ Anseloni, JE Pandossio… - Neuroscience & …, 1999 - Elsevier
Some regions in the mesencephalon, such as dorsal periaqueductal gray, inferior colliculus
and deep layers of superior colliculus have been grouped together as a continuos strip of …

Neuroanatomical approaches of the tectum-reticular pathways and immunohistochemical evidence for serotonin-positive perikarya on neuronal substrates of the …

NC Coimbra, R De Oliveira, RL Freitas, SJ Ribeiro… - Experimental …, 2006 - Elsevier
Deep layers of the superior colliculus, the dorsal periaqueductal gray matter and the inferior
colliculus are midbrain structures involved in the generation of defensive behavior and fear …

The amygdala: contributions to fear and stress

JE LeDoux - Seminars in Neuroscience, 1994 - Elsevier
Recent studies have identified major components of the neural system mediating the
classical conditioning of defense or fear responses to sensory stimuli. The pathways involve …

Brainstem correlates of defensive states in humans

JMP Baas, J Milstein, M Donlevy, C Grillon - Biological psychiatry, 2006 - Elsevier
BACKGROUND: Brainstem auditory evoked potentials (BAEP) reflect the activation of
brainstem nuclei in the first milliseconds after presentation of an auditory stimulus. These …

Neural substrate of defensive behavior in the midbrain tectum

ML Brandão, SH Cardoso, LL Melo, V Motta… - Neuroscience & …, 1994 - Elsevier
It has been shown that the gradual increase in the intensity of electrical stimulation of the
dorsal periaqueductal gray (DPAG), deep layers of the superior colliculus (DLSC) and …

Gabaergic regulation of the neural organization of fear in the midbrain tectum

ML Brandão, KG Borelli, MJ Nobre, JM Santos… - Neuroscience & …, 2005 - Elsevier
In midbrain tectum (MT) structures, such as the dorsal periaqueductal gray (dPAG), the
superior colliculus (SC) and the inferior colliculus (IC) GABAergic neurons exert a tonic …

Executive and modulatory neural circuits of defensive reactions: implications for panic disorder

NS Canteras, FG Graeff - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
The present review covers two independent approaches, a neuroanatomical and a
pharmacological (focused on serotonergic transmission), which converge in highlighting the …

Dissociation of the morphological correlates of stress‐induced anxiety and fear

JM Pêgo, P Morgado, LG Pinto… - European Journal of …, 2008 - Wiley Online Library
Chronic stress is a powerful modulator of emotional behaviour. Previous studies have
shown that distinct neuronal pathways modulate different emotional behaviours: while the …