Astrocytes play an important role in the central nervous system (CNS). Ion channels in these
cells not only function in ion transport, and maintain water/ion metabolism homeostasis, but …

The human brain is composed of nearly one hundred billion neurons and an equal number
of glial cells, including macroglia, ie, astrocytes and oligodendrocytes, and microglia, the …

The convergent endeavors of the neuroscientist to establish a link between clinical
neurology, genetics, loss of function of an important protein, and channelopathies behind …

Initial biophysical studies on glial cells nearly 50 years ago identified these cells as being
electrically silent. These first studies also demonstrated a large K+ conductance, which led …

Numerous neurodegenerative diseases result from altered ion channel function and
mutations. The intracellular redox status can significantly alter the gating characteristics of …

As the average age and life expectancy increases, the incidence of both acute and chronic
central nervous system (CNS) pathologies will increase. Understanding mechanisms …

Astrocytes have long been considered as just providing trophic support for neurons in the
central nervous system, but recently several studies have highlighted their importance in …

Neuronal signalling is a key element in neuronal communication and is essential for the
proper functioning of the CNS. Astrocytes, the most prominent glia in the brain play a key …

Glial cells are emerging as crucial players that mediate development and homeostasis of the
central nervous system (CNS). In particular, glial cells are closely associated with synapses …

Under pathological conditions microglia (resident CNS immune cells) become activated,
and produce reactive oxygen and nitrogen species and pro-inflammatory cytokines …