Abstract The Rho GTPases RhoA, Rac1, and Cdc42 are important regulators of cytoskeletal
dynamics. Although many in vitro and in vivo data indicate tumor-promoting effects of …

Involvement of Rho GTPases in cancer has been a matter of debate since the identification
of the first members of this branch of the Ras superfamily of small GTPases. The Rho …

Rho GTPases play central roles in numerous cellular processes, including cell motility, cell
polarity, and cell cycle progression, by regulating actin cytoskeletal dynamics and cell …

In vitro and in vivo studies and evidence from human tumors have long implicated Rho
GTPase signaling in the formation and dissemination of a range of cancers. Recently next …

Rho GTPases contribute to multiple cellular processes that could affect cancer progression,
including cytoskeletal dynamics, cell cycle progression, transcriptional regulation, cell …

[Frontiers in Bioscience 16, 2561-2571, June 1, 2011] Role of Rho GTPases and their regulators
in cancer progression Rajamani R Page 1 [Frontiers in Bioscience 16, 2561-2571, June 1 …

Rho GTPases are well known for their roles in regulating cell migration, and also contribute
to a variety of other cellular responses. They are subdivided into 2 groups: typical and …

As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of
cellular processes, including cell polarity, cell migration, and cell cycle progression. The …

Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

RHO GTPases have been traditionally associated with protumorigenic functions. While this
paradigm is still valid in many cases, recent data have unexpectedly revealed that RHO …