Peptide-protein interactions are very prevalent, mediating key processes such as signal
transduction and protein trafficking. How can peptides overcome the entropic cost involved …

Protein-peptide interactions play important roles in many cellular processes, including signal
transduction, trafficking, and immune recognition. Protein conformational changes upon …

Highlights•Accrual of peptide–protein complex structures allowed their detailed
characterization.•This has lead to rapid progress in peptide docking, based on diverse …

We compared the modes of interaction between protein-peptide interfaces and those
observed within monomeric proteins and found surprisingly few differences. Over 65% of …

Peptides possess several attractive features when compared to small molecule and protein
therapeutics, such as high structural compatibility with target proteins, the ability to disrupt …

Peptide‐mediated interactions, in which a short linear motif binds to a globular domain, play
major roles in cellular regulation. An accurate structural model of this type of interaction is an …

Although protein–peptide interactions are estimated to constitute up to 40% of all protein
interactions, relatively little information is available for the structural details of these …

Many cell signaling pathways are orchestrated by the weak, transient, and reversible protein–
protein interactions that are mediated by the binding of a short peptide segment in one …

Peptide-protein interactions contribute a significant fraction of the protein-protein
interactome. Accurate modeling of these interactions is challenging due to the vast …

Peptide–protein interactions are among the most prevalent and important interactions in the
cell, but a large fraction of those interactions lack detailed structural characterization. The …