Background In recent years, the role of altered cellular metabolism in tumor progression has
attracted widespread attention. Related metabolic enzymes have also been considered as …

Various enzymes in the one-carbon metabolic pathway are closely related to the
development of tumors, and they can all be potential targets for cancer therapy. Serine …

Aims: This study was launched to identify the SHMT2 associated Human Cancer subtypes.
Background: Cancer is the 2nd leading cause of death worldwide. Previous reports revealed …

Background Gastric cancer (GC) is one of the most common malignant tumours in the
digestive system. Serine hydroxymethyltransferase 2 (SHMT2) is one of the key enzymes …

The metabolic enzymes involved in one-carbon metabolism are closely associated with
tumor progression and could be potential targets for cancer therapy. Recent studies showed …

OBJECTIVE: Gastrointestinal tumors are malignant tumors with high morbidity. Mitochondrial
serine hydroxymethyltransferase 2 (SHMT2) is a key enzyme in the synthesis of serine and …

Abstract Background Serine hydroxymethyltransferase 2 (SHMT2) is a vital metabolic
enzyme in one carbon metabolism catalyzing the conversion of serine to glycine, which has …

Background Hepatocellular carcinoma (HCC) is the most major type of primary hepatic
cancer. Serine hydroxymethyltransferase 1 (SHMT1) is recently found to play critical roles in …

Esophageal cancer (EC) is a familiar digestive tract tumor with highly lethal. The hypoxic
environment has been demonstrated to be a significant factor in modulating malignant tumor …

Background: Esophageal squamous cell carcinoma (ESCC) is one of the most common
aggressive tumors in the world. m6A modification has been implicated to play an important …