The proteasome is a well-identified therapeutic target for cancer treatment. It acts as the
main protein degradation system in the cell and degrades key mediators of cell growth …

The proteasome is the central component of the main cellular protein degradation pathway.
During the past four decades, the critical function of the proteasome in numerous …

The proteasome is a multicatalytic protease and the principal non-lysosomal proteolytic
system in all eukaryotic cells. It plays a central role in virtually all regulatory pathways as for …

As the central figure of the cellular protein degradation machinery, the proteasome is critical
for cell survival. Having been extensively targeted for inhibition, the constitutive proteasome …

Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …

The ubiquitin proteasome system (UPS) degrades individual proteins in a highly regulated
fashion and is responsible for the degradation of misfolded, damaged, or unneeded cellular …

Proteins actively participate in a wide range of cellular physiological functions. But
aggregation of proteins results in cytotoxicity, and unwanted aggregation of misfolded …

Selective degradation of proteins by the ubiquitin-proteasome pathway is a critical
determinant for maintaining cellular homeostasis. Most intracellular proteins are degraded …

Proteasome is a multi-subunit protein degradation machine, which plays a key role in the
maintenance of protein homeostasis and, through degradation of regulatory proteins, in the …

In cells, protein degradation is a key pathway for the destruction of abnormal or damaged
proteins as well as for the elimination of proteins whose presence is no longer required …