Background The long-term natural history of chronic obstructive pulmonary disease (COPD)
in terms of successive severe exacerbations and mortality is unknown. Methods The authors …

Rationale: Acute exacerbations of chronic obstructive pulmonary disease (AECOPDs) are
important adverse events in the natural history of chronic obstructive pulmonary disease …

Introduction Natural history of chronic obstructive pulmonary disease (COPD) is punctuated
by exacerbations; however, little is known about prognosis of the first-ever COPD …

Background: Patients with chronic obstructive pulmonary disease (COPD) often present with
severe acute exacerbations requiring hospital treatment. However, little is known about the …

Background The natural history and time course of the onset of exacerbation events of
chronic obstructive pulmonary disease (COPD) is incompletely understood. Methods A …

Rationale: Exacerbations are important and heterogeneous events in the natural history of
chronic obstructive pulmonary disease (COPD). Objectives: To examine the consequences …

Acute exacerbations of chronic obstructive pulmonary disease (AECOPDs) are episodes of
symptom worsening 1 that have significant adverse consequences for patients. 2 The …

Background and aim Mortality rate is high in patients with chronic obstructive pulmonary
disease (COPD). Our aim was to investigate long-term mortality and associated risk factors …

Background Exacerbations affect morbidity in chronic obstructive pulmonary disease
(COPD). We sought to evaluate the association between exacerbation frequency and …

Exacerbations are an important feature and outcome measure in chronic obstructive
pulmonary disease (COPD), but little is known about changes in their severity, recovery …