Ketamine has shown rapid antidepressant and anti-suicidal effects in treatment-resistant
depression (TRD) with single and serial intravenous (IV) infusions, but the effectiveness for …

Background: The therapeutic potential of subanesthetic doses of ketamine appears
promising in unipolar depression; however, its effectiveness in treating bipolar depression …

Background Due to unmet clinical needs for efficient drugs with a rapid onset of
antidepressant effects, we aimed to evaluate the efficacy of single-dose ketamine in different …

Background: Clinical trials have demonstrated rapid antidepressant effects with intravenous
(IV) ketamine for major depressive disorder, with relatively less research specifically for …

Background Ketamine, a glutamate N-methyl-d-aspartate receptor antagonist, has shown
rapid antidepressant effects in treatment-resistant depression. We conducted a systematic …

Background Unipolar and bipolar depression present treatment challenges, with patients
sometimes showing limited or no response to standard medications. Ketamine and its …

Abstract Major Depressive Disorder (MDD) is a common psychiatric disorder with major
implications for healthcare system and socioeconomic burden. For chronic and treatment …

Objective The current meta‐analysis examines the effects of ketamine infusion on
depressive symptoms over time in major depressive disorder (MDD) and bipolar disorder …

Objective: To consolidate the evidence from the literature to evaluate the role of ketamine in
the treatment of bipolar depression. Methods: Major databases, including MEDLINE …

Purpose Bipolar disorder is a chronic and recurrent condition often associated with
treatment resistance and suicidality. There is an unmet need for effective treatment in this …