Over 80% of ovarian cancer patients develop chemoresistance which results in a lethal
course of the disease. A well-established cause of chemoresistance involves the family of …

OBJECTIVE: ATP-binding Cassette (ABC) transporters are thought to cause multiple drug
resistance (MDR) in various carcinomas. Gene expression data from individual transporters …

Cancer is one of the leading causes of mortality in the developed countries. The search for
novel drug candidates is a priority goal for cancer therapy. However, the emergence of drug …

The ATP-binding cassette transporters (ABC transporters) have been intensely studied over
the past 50 years for their involvement in the multidrug resistance (MDR) phenotype …

ATP-binding cassette (ABC) transporters are membrane-spanning proteins involved in
cholesterol homeostasis, transport of various molecules in and out of cells and organelles …

The phenomenon of multidrug resistance in cancer is often associated with the
overexpression of the ABC (ATP-binding cassette) transporters Pgp (P …

Background ATP-binding cassette (ABC) transporters play various roles in cancer biology
and drug resistance, but their association with outcomes in serous epithelial ovarian cancer …

Overexpression of ATP-binding cassette (ABC) transporters is a cause of drug resistance in
a plethora of tumors. More recent evidence indicates additional contribution of these …

The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …

PURPOSE: Efflux transporters of the ATP-binding cassette (ABC) family are major
determinants of chemoresistance in tumor cells. This study examined associations between …