The KDM5 family of histone demethylases catalyzes the demethylation of histone H3 on
lysine 4 (H3K4) and is required for the survival of drug-tolerant persister cancer cells (DTPs) …

Lysine-specific histone demethylase 3 (KDM3) subfamily proteins are H3K9me2/me1
histone demethylases that promote gene expression. The KDM3 subfamily primarily consists …

Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …

KDM4 histone demethylases catalyze the removal of methyl marks from histone lysine
residues to epigenetically regulate chromatin structure and gene expression. KDM4 …

Histone methylation is important in the regulation of genes expression, and thus its
dysregulation has been observed in various cancers. KDM5 enzymes are capable of …

Members of the KDM5 (also known as JARID1) family are 2-oxoglutarate-and Fe2+-
dependent oxygenases that act as histone H3K4 demethylases, thereby regulating cell …

Histone N ε-methyl lysine demethylases KDM2/7 have been identified as potential targets for
cancer therapies. On the basis of the crystal structure of KDM7B, we designed and prepared …

The discovery of histone demethylases has revealed the dynamic nature of the regulation of
histone methylation. KDM2B is an important histone lysine demethylase that removes methyl …

Histone posttranslational modifications are important components of epigenetic regulation.
One extensively studied modification is the methylation of lysine residues. These …

Lysine-specific demethylase 5A (KDM5A), an enzyme that removes activating H3K4 di-and
trimethylation marks, plays critical roles in controlling transcription and chromatin …