Anxiety is of paramount importance for animals, as it allows assessment of the environment
while minimizing exposure to potential threats. Furthermore, anxiety disorders are highly …

Anxiety disorders impose a staggering burden on public health, underscoring the need to
develop a deeper understanding of the distributed neural circuits underlying extreme fear …

The central amygdala (CeA) is important for fear responses to discrete cues. Recent findings
indicate that the CeA also contributes to states of sustained apprehension that characterize …

Anxiety is an aversive mood reflecting the anticipation of potential threats. The ventral
hippocampus (vH) is a key brain region involved in the genesis of anxiety responses …

Anxiety is an adaptive response to potentially threatening situations. Exaggerated and
uncontrolled anxiety responses become maladaptive and lead to anxiety disorders. Anxiety …

Although anxiety disorders represent a major societal problem demanding new therapeutic
targets, these efforts have languished in the absence of a mechanistic understanding of this …

We suggest that to understand complex behaviors associated with fear and anxiety, we
need to understand brain processes at the collective, network level. But what should be the …

Elucidation of the 'fear circuit'has opened exciting avenues for understanding and treating
human anxiety disorders. However, the translation of rodent to human studies, and vice …

Responses of the insular cortex (IC) and amygdala to stimuli of positive and negative
valence are altered in patients with anxiety disorders. However, neural coding of both …

Stress and anxiety have intertwined behavioral and neural underpinnings. These
commonalities are critical for understanding each state, as well as their mutual interactions …