Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …

The introduction of antiretroviral therapy (ART) 20 years ago has dramatically reduced
morbidity and mortality associated with HIV-1. Initially there was hope that ART would be …

Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target
proviral populations in cells that persist for prolonged periods and that can undergo clonal …

Although antiretroviral therapies (ARTs) potently inhibit HIV replication, they do not eradicate
the virus. HIV persists in cellular and anatomical reservoirs that show minimal decay during …

HIV-1 can infect both activated and resting, non-dividing cells, following which the viral
genome can be permanently integrated into a host cell chromosome. Latent HIV-1 reservoirs …

Thirty-five years after the identification of HIV-1 as the causative agent of AIDS, we are still in
search of vaccines and treatments to eradicate this devastating infectious disease. Progress …

HIV-1 infection persists even after years of antiretroviral therapy (ART). Although ART can
halt viral replication and thereby reduce viremia to clinically undetectable levels, proviral …

Although antiretroviral therapy (ART) is highly effective at suppressing HIV-1 replication, the
virus persists as a latent reservoir in resting CD4+ T cells during therapy. This reservoir …

Highly active antiretroviral therapy (HAART) suppresses HIV-1 replication, transforming the
outlook for infected patients. However, reservoirs of replication-competent forms of the virus …

Stable remission is the ultimate goal of HIV therapy. A review of recent studies on the ability
of HIV to persist despite highly active antiretroviral therapy (HAART) and immune stimulation …