Impaired dynamics of brain precapillary sphincters and pericytes at first order capillaries explains reduced neurovascular functions in aging
The microvascular inflow tract (MIT), comprising the penetrating arterioles, precapillary
sphincters, and first order capillaries, is the bottleneck for brain blood flow and energy …
sphincters, and first order capillaries, is the bottleneck for brain blood flow and energy …
Impaired dynamics of precapillary sphincters and pericytes at first-order capillaries predict reduced neurovascular function in the aging mouse brain
The microvascular inflow tract, comprising the penetrating arterioles, precapillary sphincters
and first-order capillaries, is the bottleneck for brain blood flow and energy supply. Exactly …
and first-order capillaries, is the bottleneck for brain blood flow and energy supply. Exactly …
[PDF][PDF] Deficiency in pericyte remodeling as a basis for impaired capillary flow and structure during brain aging
AA Berthiaume, F Schmid, S Stamenkovic, V Santos… - bioRxiv, 2022 - scholar.archive.org
Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
[HTML][HTML] Emerging links between cerebral blood flow regulation and cognitive decline: A role for brain microvascular pericytes
TY You, Q Dong, M Cui - Aging and Disease, 2023 - ncbi.nlm.nih.gov
Cognitive impairment associated with vascular etiology has been of considerable interest in
the development of dementia. Recent studies have started to uncover cerebral blood flow …
the development of dementia. Recent studies have started to uncover cerebral blood flow …
Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure
Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo
Brains depend on blood flow for the delivery of oxygen and nutrients essential for proper
neuronal and synaptic functioning. French physiologist Rouget was the first to describe …
neuronal and synaptic functioning. French physiologist Rouget was the first to describe …
Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion
Rises in local neural activity trigger local increases of cerebral blood flow, which is essential
to match local energy demands. However, the specific location of microvascular flow control …
to match local energy demands. However, the specific location of microvascular flow control …
Aging drives cerebrovascular network remodeling and functional changes in the mouse brain
Aging is frequently associated with compromised cerebrovasculature and pericytes.
However, we do not know how normal aging differentially impacts vascular structure and …
However, we do not know how normal aging differentially impacts vascular structure and …
Senescence in brain pericytes attenuates blood-brain barrier function in vitro: a comparison of serially passaged and isolated pericytes from aged rat brains
T Iwao, F Takata, J Matsumoto, Y Goto… - Biochemical and …, 2023 - Elsevier
Aging is associated with the dysfunction of the blood-brain barrier (BBB), which comprises
brain microvessel endothelial cells (BMECs), astrocytes, and pericytes. Pericytes are …
brain microvessel endothelial cells (BMECs), astrocytes, and pericytes. Pericytes are …
[HTML][HTML] Pericytes: blood-brain barrier safeguards against neurodegeneration?
A Quaegebeur, I Segura, P Carmeliet - Neuron, 2010 - cell.com
The role of pericytes in the control of blood-brain barrier (BBB) integrity has remained
enigmatic. In this issue, Bell et al. and two concurrent studies highlight that pericyte loss …
enigmatic. In this issue, Bell et al. and two concurrent studies highlight that pericyte loss …