Macropinocytosis has emerged as an important nutrient-scavenging pathway that supports
tumor cell fitness. By internalizing extracellular protein and targeting it for lysosomal …

Although pancreatic ductal adenocarcinoma (PDAC) cells are exposed to a nutrient-
depleted tumor microenvironment, they can acquire nutrients via macropinocytosis, an …

Oncogenic mutations, such as Ras mutations, drive not only enhanced proliferation but also
the metabolic adaptations that confer to cancer cells the ability to sustain cell growth in a …

In tumour cells, macropinocytosis functions as an amino acid supply route and supports
cancer cell survival and proliferation. Initially demonstrated in oncogenic KRAS-driven …

Macropinocytosis is an evolutionarily conserved endocytic pathway that mediates the
nonselective acquisition of extracellular material via large endocytic vesicles known as …

Macropinocytosis, an evolutionarily conserved endocytic mechanism that mediates non-
specific fluid-phase uptake, is potently upregulated by various oncogenic pathways. It is now …

Macropinocytosis is an important nutrient-scavenging pathway in numerous cancer types,
including pancreatic, lung, prostate, and bladder. This Forum highlights recent work …

Cancer cells can adapt to nutrient poor conditions by rewiring their metabolism and using
alternate fuel sources. Identifying these adaptive metabolic pathways may provide novel …

Macropinocytosis is an evolutionarily conserved form of endocytosis that mediates non-
selective uptake of extracellular fluid and the solutes contained therein. In mammalian cells …

Stress-adaptive mechanisms enable tumour cells to overcome metabolic constraints under
nutrient and oxygen shortage. Aspartate is an endogenous metabolic limitation under …