Inflammasomes are large cytosolic multiprotein complexes assembled in response to
infection and cellular stress, and are crucial for the activation of inflammatory caspases and …

Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

Germline-encoded pattern recognition receptors (PRRs) sense microbial or endogenous
products released from damaged or dying cells and trigger innate immunity. In most cases …

The inflammasomes are innate immune system receptors and sensors that regulate the
activation of caspase-1 and induce inflammation in response to infectious microbes and …

Inflammation is a body's protective mechanism to eliminate invading pathogens and cellular
damaging signals. The inflammatory response consists of two main consecutive steps—a …

Inflammasomes are multiprotein complexes of the innate immune system that orchestrate
development of inflammation by activating the secretion of proinflammatory cytokines, IL-1β …

Inflammatory responses mediated by macrophages are part of the innate immune system,
whose role is to protect against invading pathogens. Lipopolysaccharide (LPS) found in the …

Inflammation is an immune response mediated by innate immune cells of tissues, against
invading microbes and cellular stress. The hallmark of inflammatory responses is the …

Inflammasomes are critical for host defense against bacterial pathogens. In murine
macrophages infected by gram-negative bacteria, the canonical inflammasome activates …

Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …