Development of OA (OA) is multifactorial and is strongly associated with risk factors such as
aging, trauma, metabolic disorders, and obesity. Metabolic Syndrome (MetS)-associated OA …

Osteoarthritis (OA) is a multifactorial disease contributing to significant disability and
economic burden in Western populations. The aetiology of OA remains poorly understood …

Sir Archibald Edward Garrod, who pioneered the field of inborn errors of metabolism and
first elucidated the biochemical basis of alkaptonuria over 100 years ago, suggested that …

Increasing evidence implicates metabolic dysfunction in the development and progression
of osteoarthritis (OA). Large-scale'omics' studies, particularly metabolomics, have the …

Arthritic diseases are a major cause of disability and morbidity, and cause an enormous
burden for health and social care systems globally. Osteoarthritis (OA) is the most common …

Objective To highlight the advances over the past year in metabolite/protein biomarkers for
osteoarthritis (OA). Method A literature search of five databases including PubMed, Web of …

Objective Obesity was once considered a risk factor for knee osteoarthritis (OA) primarily for
biomechanical reasons. Here we provide an additional perspective by discussing how …

Osteoarthritis (OA) is a progressive, deteriorative disease of articular joints. Although
traditionally viewed as a local pathology, biomarker exploration has shown that systemic …

Osteoarthritis (OA) is one of the most debilitating diseases affecting mankind with severe
financial and emotional consequences. The heterogeneity of the human population, lack of …

Objective The aim of this narrative review is to summarize important findings from
biochemical marker studies relevant to osteoarthritis (OA) in the context of new discoveries …