Peptide antigens expressed in the thupaus, in combination with self major histocompatibility
complex molecules, play a crucial role in thymocyte selection and shaping of the mature T …

T cells are spared from programed cell death in the thymus after an appropriate interaction
between the T-cell receptor and a self peptide/MHC complex; this step is referred to as …

The development of an anticipatory immune system requires it to acquire the capacity to
recognize a spectrum of potential pathogens, none of which it has encountered during its …

In the thymus, positive and negative selection shape the T cell repertoire. It has previously
been shown that positive selection, like negative selection, is the result of the interaction of …

Positive and negative selection in the thymus occur when the TCR on an immature
thymocyte engages self peptide/MHC complexes present on epithelial cells. The signaling …

The fate of developing T cells is specified by the interaction of their antigen receptors with
self-peptide–MHC complexes that are displayed by thymic antigen-presenting cells (APCs) …

Thymocytes are positively or negatively selected depending on interactions between their T
cell receptors (TCR) and peptides presented by major histocompatibility complex molecules …

During T cell development, thymocytes which are tolerant to self-peptides but reactive to
foreign peptides are selected. The current model for thymocyte selection proposes that self …

Michael J. Bevan cells of the thymus are the cells responsible for pre-Howard Hughes
Medical Institute senting MHC ligands to immature T cells. Lethally irradi-Department of …

We set out to determine whether thymocytes from T cell receptor (TCR) transgenic animals
specific for a class I‐restricted determinant from ovalbumin (OVA) showed the same fine …