[HTML][HTML] CD36 in Alzheimer's disease: an overview of molecular mechanisms and therapeutic targeting
CD36 is a membrane protein with wide distribution in the human body, is enriched in the
monocyte-macrophage system and endothelial cells, and is involved in the cellular uptake of …
monocyte-macrophage system and endothelial cells, and is involved in the cellular uptake of …
CD36–A novel molecular target in the neurovascular unit
O Ioghen, L Chițoiu, M Gherghiceanu… - European Journal of …, 2021 - Wiley Online Library
CD36 is an integral membrane protein primarily known for its function as a fatty acid
transporter, yet also playing other biological roles from lipid metabolism to inflammation …
transporter, yet also playing other biological roles from lipid metabolism to inflammation …
CD36 overexpression in human brain correlates with β-amyloid deposition but not with Alzheimer's disease
R Ricciarelli, C d'Abramo, JM Zingg, L Giliberto… - Free Radical Biology …, 2004 - Elsevier
Scavenger receptors recently have been related to Alzheimer's disease, although it is still
unclear whether they contribute to the pathogenesis of the disease or reflect an inflammatory …
unclear whether they contribute to the pathogenesis of the disease or reflect an inflammatory …
Role of CD36 in central nervous system diseases
M Feng, Q Zhou, H Xie, C Liu, M Zheng… - Neural Regeneration …, 2023 - journals.lww.com
CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger
receptor class B family and regulates the pathological progress of metabolic diseases. CD36 …
receptor class B family and regulates the pathological progress of metabolic diseases. CD36 …
CD36 mediates the innate host response to β-amyloid
Accumulation of inflammatory microglia in Alzheimer's senile plaques is a hallmark of the
innate response to β-amyloid fibrils and can initiate and propagate neurodegeneration …
innate response to β-amyloid fibrils and can initiate and propagate neurodegeneration …
Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-β
L Park, G Wang, P Zhou, J Zhou… - Proceedings of the …, 2011 - National Acad Sciences
Increasing evidence indicates that cerebrovascular dysfunction plays a pathogenic role in
Alzheimer's dementia (AD). Amyloid-β (Aβ), a peptide central to the pathogenesis of AD, has …
Alzheimer's dementia (AD). Amyloid-β (Aβ), a peptide central to the pathogenesis of AD, has …
CD36: A multi‐modal target for acute stroke therapy
S Cho, E Kim - Journal of neurochemistry, 2009 - Wiley Online Library
A role for CD36 in the pathogenesis of atherosclerosis, inflammation and lipid metabolism
has been well‐documented. However, little is known about the role of CD36 in cerebral …
has been well‐documented. However, little is known about the role of CD36 in cerebral …
[HTML][HTML] β-Amyloid promotes accumulation of lipid peroxides by inhibiting CD36-mediated clearance of oxidized lipoproteins
VV Kunjathoor, AA Tseng, LA Medeiros, T Khan… - Journal of …, 2004 - Springer
Background Recent studies suggest that hypercholesterolemia, an established risk factor for
atherosclerosis, is also a risk factor for Alzheimer's disease. The myeloid scavenger receptor …
atherosclerosis, is also a risk factor for Alzheimer's disease. The myeloid scavenger receptor …
Impact of the CD40-CD40L dyad in Alzheimer's disease
As the number of elderly individuals rises, Alzheimer's disease (AD), marked by amyloid-β
deposition, neurofibrillary tangle formation, and low-level neuroinflammation, is expected to …
deposition, neurofibrillary tangle formation, and low-level neuroinflammation, is expected to …
CD33 in Alzheimer's disease–biology, pathogenesis, and therapeutics: a mini-review
L Zhao - Gerontology, 2019 - karger.com
Alzheimer's disease (AD) affects nearly 50 million people worldwide, and currently no
disease-modifying treatment is available. With continuous failure of anti-amyloid-beta-or tau …
disease-modifying treatment is available. With continuous failure of anti-amyloid-beta-or tau …