[HTML][HTML] CD36 in Alzheimer's disease: an overview of molecular mechanisms and therapeutic targeting

AM Dobri, M Dudău, AM Enciu, ME Hinescu - Neuroscience, 2021 - Elsevier
CD36 is a membrane protein with wide distribution in the human body, is enriched in the
monocyte-macrophage system and endothelial cells, and is involved in the cellular uptake of …

CD36–A novel molecular target in the neurovascular unit

O Ioghen, L Chițoiu, M Gherghiceanu… - European Journal of …, 2021 - Wiley Online Library
CD36 is an integral membrane protein primarily known for its function as a fatty acid
transporter, yet also playing other biological roles from lipid metabolism to inflammation …

CD36 overexpression in human brain correlates with β-amyloid deposition but not with Alzheimer's disease

R Ricciarelli, C d'Abramo, JM Zingg, L Giliberto… - Free Radical Biology …, 2004 - Elsevier
Scavenger receptors recently have been related to Alzheimer's disease, although it is still
unclear whether they contribute to the pathogenesis of the disease or reflect an inflammatory …

Role of CD36 in central nervous system diseases

M Feng, Q Zhou, H Xie, C Liu, M Zheng… - Neural Regeneration …, 2023 - journals.lww.com
CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger
receptor class B family and regulates the pathological progress of metabolic diseases. CD36 …

CD36 mediates the innate host response to β-amyloid

JB El Khoury, KJ Moore, TK Means, J Leung… - The Journal of …, 2003 - rupress.org
Accumulation of inflammatory microglia in Alzheimer's senile plaques is a hallmark of the
innate response to β-amyloid fibrils and can initiate and propagate neurodegeneration …

Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-β

L Park, G Wang, P Zhou, J Zhou… - Proceedings of the …, 2011 - National Acad Sciences
Increasing evidence indicates that cerebrovascular dysfunction plays a pathogenic role in
Alzheimer's dementia (AD). Amyloid-β (Aβ), a peptide central to the pathogenesis of AD, has …

CD36: A multi‐modal target for acute stroke therapy

S Cho, E Kim - Journal of neurochemistry, 2009 - Wiley Online Library
A role for CD36 in the pathogenesis of atherosclerosis, inflammation and lipid metabolism
has been well‐documented. However, little is known about the role of CD36 in cerebral …

[HTML][HTML] β-Amyloid promotes accumulation of lipid peroxides by inhibiting CD36-mediated clearance of oxidized lipoproteins

VV Kunjathoor, AA Tseng, LA Medeiros, T Khan… - Journal of …, 2004 - Springer
Background Recent studies suggest that hypercholesterolemia, an established risk factor for
atherosclerosis, is also a risk factor for Alzheimer's disease. The myeloid scavenger receptor …

Impact of the CD40-CD40L dyad in Alzheimer's disease

B Giunta, K Rezai-Zadeh, J Tan - CNS & Neurological …, 2010 - ingentaconnect.com
As the number of elderly individuals rises, Alzheimer's disease (AD), marked by amyloid-β
deposition, neurofibrillary tangle formation, and low-level neuroinflammation, is expected to …

CD33 in Alzheimer's disease–biology, pathogenesis, and therapeutics: a mini-review

L Zhao - Gerontology, 2019 - karger.com
Alzheimer's disease (AD) affects nearly 50 million people worldwide, and currently no
disease-modifying treatment is available. With continuous failure of anti-amyloid-beta-or tau …