Glaucoma is a leading cause of permanent blindness worldwide and is characterized by
neurodegeneration linked to progressive retinal ganglion cell (RGC) death, axonal damage …

Abstract Sphingosine-1-phosphate receptor (S1PR) signaling regulates diverse
pathophysiological processes in the central nervous system. The role of S1PR signaling in …

Glaucoma is a complex neurodegenerative disease characterized by optic nerve damage
and apoptotic retinal ganglion cell (RGC) death, and is the leading cause of irreversible …

This study aims to study the potentials of sulforaphane (SFN) against retinal
ischemia/reperfusion (I/R) injury. A rat retinal I/R injury method was established. Retinal …

N-methyl-N-nitrosourea (NMU) is widely used to model oxidative stress and inflammation
mediated retinal neurodegeneration. Wedelolactone (WD) is known to have antioxidant, anti …

Background Indirect traumatic optic neuropathy (ITON) is a major cause of permanent loss of
vision after blunt head trauma. Neuroinflammation plays a crucial role in neurodegenerative …

Glutamate excitotoxicity may contribute to retinal ganglion cell (RGC) degeneration in
glaucoma and other optic neuropathies, leading to irreversible blindness. Growing evidence …

In this study, we used a classical optic nerve injury model to address the function of the
sphingosine 1‐phosphate (S1P)–S1P receptor (S1PR) axis in retinal ganglion cell (RGC) …

N-methyl-D-aspartate (NMDA)-induced excitotoxicity is an acute form of experimental retinal
injury as a result of overactivation of glutamate receptors. NLRP3 (nucleotide-binding …

Background Inflammation and the excess production of reactive oxygen species (ROS)
contribute significantly to the pathogenesis of ischemic retinopathies such as diabetic …