Translation and ribosome biogenesis in mitochondria require auxiliary factors that ensure
rapid and accurate synthesis of mitochondrial proteins. Defects in translation are associated …

Most steps on the biogenesis of the mitochondrial ribosome (mitoribosome) occur near the
mitochondrial DNA nucleoid, in RNA granules, which contain dedicated RNA metabolism …

Mitochondria contain their own genetic information and a dedicated translation system to
express it. The mitochondrial ribosome is assembled from mitochondrial-encoded RNA and …

Ribosome biogenesis requires auxiliary factors to promote folding and assembly of
ribosomal proteins and RNA. Particularly, maturation of the peptidyl transferase center (PTC) …

Human mitoribosomes are macromolecular complexes essential for translation of 11
mitochondrial mRNAs. The large and the small mitoribosomal subunits undergo a multistep …

The human mitochondrial translation apparatus, which synthesizes the core subunits of the
oxidative phosphorylation system, is of central interest as mutations in several genes …

Biogenesis of mammalian mitochondrial ribosomes (mitoribosomes) involves several
conserved small GTPases. Here, we report that the Obg family protein GTPBP5 or MTG2 is a …

Mitochondrial ribosomes (mitoribosomes) synthesize a critical set of proteins essential for
oxidative phosphorylation. Therefore, mitoribosomal function is vital to the cellular energy …

Mammalian mitochondrial ribosomes (mitoribosomes) are responsible for synthesizing
proteins that are essential for oxidative phosphorylation (ATP generation). Despite their …

The molecular mechanism of human mitochondrial translation has yet to be fully described.
We are particularly interested in understanding the process of translational termination and …