Exercise training is critical for the prevention and treatment of obesity, but its underlying
mechanisms remain incompletely understood given the challenge of profiling …

Here, we enriched a human cell population from adipose tissue that exhibited both
mesenchymal plasticity, self-renewal capacity, and a cell-surface marker profile …

Obesity is associated with a variety of disorders including cardiovascular diseases, diabetes
mellitus and cancer. Obesity changes the composition and structure of adipose tissue, linked …

Adipose-derived stem cells (ASCs) have been increasingly used as a versatile source of
mesenchymal stem cells (MSCs) for diverse clinical investigations. However, their …

Obesity is now a major public health problem worldwide. Lifestyle modification to reduce the
characteristic excess body adiposity is important in the treatment of obesity, but effective …

Obesity and metabolic disorders such as type 2 diabetes mellitus are accompanied by
increased lipid deposition in adipose and non-adipose tissues including liver, pancreas …

Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

Background Ageing is accompanied by sarcopenia and intramuscular fat (IMAT) infiltration.
In skeletal muscle, fat infiltration is a common feature in several myopathies and is …

Regeneration of mesenchymal tissues depends on a resident stem cell population, that in
most cases remains elusive in terms of cellular identity and differentiation signals. We here …

Inflammation and lipid accumulation are hallmarks of muscular pathologies resulting from
metabolic diseases such as obesity and type 2 diabetes. During obesity, the hypertrophy of …