Piezo1 is a mechanically-gated calcium channel. Recent studies have shown that Piezo1, a
mechanically-gated calcium channel, can attenuate both psychosine-and …

Astrocytes are important for information processing in the brain and they achieve this by fine‐
tuning neuronal communication via continuous uptake and release of biochemical …

Piezo1 mechanosensitive ion channel (MSC) plays a significant role in human physiology.
Despite several research on the function and expression of Piezo1 in the nervous system, its …

Stroke is associated with high mortality and extremely high disability rate. Regulating
ferroptosis seems to be a promising way to treat ischemic stroke. After stroke, vasogenic …

Abstract Objective We investigated whether Piezo1 could regulate oxygen-glucose
deprivation/reoxygenation injury of neurons through Ca 2+/calpain signaling. Methods …

Microglial cells are crucial in maintaining central nervous system (CNS) homeostasis and
mediating CNS disease pathogenesis. Increasing evidence supports that alterations in the …

Mechanosensors are emerging players responding to hemodynamic and physical inputs.
Their significance in the central nervous system remains relatively uncharted. Using human …

Piezo1 is a mechanosensitive ion channel that facilitates the translation of extracellular
mechanical cues to intracellular molecular signaling cascades through a process termed …

Microglia are the brain's resident immune cells, performing surveillance to promote
homeostasis and healthy functioning. While microglial chemical signaling is well-studied …

Upon injury, the direct damage and the subsequent secondary injury in the brain often result
in chronic neurological disorders. Due to multifactorial nature of secondary injury and …