Systems Toxicology is the integration of classical toxicology with quantitative analysis of
large networks of molecular and functional changes occurring across multiple levels of …

Systems Toxicology aims to change the basis of how adverse biological effects of
xenobiotics are characterized from empirical end points to describing modes of action as …

High‐throughput toxicity testing technologies along with the World Wide Web are
revolutionizing both generation of and access to data regarding the biological activities that …

The applications of systems biology approaches have greatly increased in the past decade
largely as a consequence of the human genome project and technological advances in …

Environmental mixtures of chemicals constitute a prevalent issue in ecotoxicology and the
development of new methods to reduce the uncertainties associated with their ecological …

Despite wide-spread consensus on the need to transform toxicology and risk assessment in
order to keep pace with technological and computational changes that have revolutionized …

The need for a more mechanistic understanding of the ways in which chemicals modulate
biological pathways is urgent if we are to identify and better assess safety issues relating to …

Pollution represents a leading threat to global health and ecosystems. Systems-based
initiatives, including Planetary Health, EcoHealth, and One Health, require theoretical and …

Computational toxicology is the application of mathematical and computer models to help
assess chemical hazards and risks to human health and the environment. Supported by …

The adverse outcome pathway (AOP) framework serves as a knowledge assembly,
interpretation, and communication tool designed to support the translation of pathway …