ABCA1, an ATP-binding cassette (ABC) subfamily A exporter, mediates the cellular efflux of
phospholipids and cholesterol to the extracellular acceptor apolipoprotein AI (apoA-I) for …

Recent studies of Tangier disease have shown that the ATP-binding cassette transporter A1
(ABCA1)/apolipoprotein AI (apoA-I) interaction is critical for high density lipoprotein particle …

The ABCA1 transporter contains two large domains into which many of the genetic
mutations in individuals with Tangier disease fall. To investigate the structural requirements …

ABCA1 mediates the secretion of cellular free cholesterol and phospholipids to an
extracellular acceptor, apolipoprotein AI, to form nascent high‐density lipoprotein (HDL) …

We have previously established that the ABCA1 transporter, which plays a critical role in the
lipidation of extracellular apolipoprotein acceptors, traffics between late endocytic vesicles …

ATP-binding cassette transporter 1 (ABCA1), the defective transporter in Tangier disease,
binds and promotes cellular cholesterol and phospholipid efflux to apolipoprotein I (apoA-I) …

ABCA1 mediates release of cellular cholesterol and phospholipid to form high density
lipoprotein (HDL). The three different mutants in the first extracellular domain of human …

Mutations in the ATP-binding cassette transporter A1 (ABCA1) transporter are associated
with Tangier disease and a defect in cellular cholesterol efflux. The amino terminus of the …

Lipid-poor apolipoproteins remove cellular cholesterol and phospholipids by an active
transport pathway controlled by an ATP binding cassette transporter called ABCA1 (formerly …

The identification of defects in ABCA1 as the molecular basis of Tangier disease has
highlighted its crucial role in the loading with phospholipids and cholesterol of nascent …