The athlete's heart vs. the failing heart: can signaling explain the two distinct outcomes?

KL Weeks, JR McMullen - Physiology, 2011 - journals.physiology.org
Cardiac remodeling is typically associated with disease and can lead to heart failure. In
contrast, remodeling that occurs in the athlete's heart is considered an adaptive …

Differences between pathological and physiological cardiac hypertrophy: novel therapeutic strategies to treat heart failure.

JR McMullen, GL Jennings - Clinical & Experimental …, 2007 - search.ebscohost.com
In general, cardiac hypertrophy (an increase in heart mass) is a poor prognostic sign.
Cardiac enlargement is a characteristic of most forms of heart failure. Cardiac hypertrophy …

Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies

BC Bernardo, KL Weeks, L Pretorius… - Pharmacology & …, 2010 - Elsevier
Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …

Acute and chronic response to exercise in athletes: the “supernormal heart”

A D'Andrea, T Formisano, L Riegler, R Scarafile… - … Disease Prevention and …, 2017 - Springer
During last decades, most studies have examined the exercise-induced remodeling defined
as “athlete's heart”. During exercise, there is an increased cardiac output that causes …

[HTML][HTML] Cardiac damage in athlete's heart: When the “supernormal” heart fails!

A Carbone, A D'Andrea, L Riegler… - World journal of …, 2017 - ncbi.nlm.nih.gov
Intense exercise may cause heart remodeling to compensate increases in blood pressure or
volume by increasing muscle mass. Cardiac changes do not involve only the left ventricle …

Cardiac adaptation to exercise training in health and disease

DY Seo, HB Kwak, AH Kim, SH Park, JW Heo… - … -European Journal of …, 2020 - Springer
The heart is the primary pump that circulates blood through the entire cardiovascular system,
serving many important functions in the body. Exercise training provides favorable …

Hallmarks of exercised heart

Y Qiu, X Pan, Y Chen, J Xiao - Journal of Molecular and Cellular Cardiology, 2022 - Elsevier
The benefits of exercise in humans on the heart have been well recognized for many years.
Long-term endurance exercise training can induce physiologic cardiac hypertrophy with …

Sports-specific adaptations and differentiation of the athlete's heart

A Urhausen, W Kindermann - Sports Medicine, 1999 - Springer
Although the sports-specific adaptations and differentiation of an athlete's heart (AH) were
first described 100 years ago, the condition is still an area of active debate. In clinical …

Left ventricular hypertrophy in athletes: morphologic features and clinical correlates

AE Atchley Jr, PS Douglas - Cardiology clinics, 2007 - Elsevier
The athlete's heart is a constellation of cardiac morphologic changes, including increased
left ventricular volume, increased left ventricular mass, increased left atrial volume, and right …

Left ventricular hypertrophy in athletes and hypertensive patients

D Lovic, P Narayan, A Pittaras, C Faselis… - The Journal of …, 2017 - Wiley Online Library
Systemic hypertension and physical exercise are both associated with cardiac adaptations.
The impact is most prominent on the left side of the heart, which hypertrophies leading to left …