A limited number of peripheral targets generate pain. Inflammatory mediators can sensitize
these. The review addresses targets acting exclusively or predominantly on sensory …

Pain is recognized as a multifactorial sensory experience that is wholly unpleasant. It can
vary in intensity from mild to severe and its duration can be anything from transient to …

Neuronal injury not only results in severe alteration in the function of primary sensory
neurons and their central projection pathway, but is also associated with a robust immune …

Aim Despite an improved understanding of the molecular mechanisms of nociception,
existing analgesic drugs remain limited in terms of efficacy in chronic conditions, such as …

Primary afferent nociceptors can “listen” to immune cells by sensing cytokines that are
released at the site of acute inflammation or maintained inflammatory processes in case of …

The “Non-pharmacological treatment of pain” section of the Frontiers in Pain Research was
initiated to reflect the growing appreciation for the role that complementary interventions play …

Pain is one of the most fundamental sensations necessary for survival. Pain teaches
individuals to avoid harm, to control their body, to allow for healing of injuries, and to better …

Pharmacological approaches to our understanding and treatment of pain have had a long
history and have traditionally relied on very few drugs that either have significant side effects …

Receptors that are involved in generation and transduction of pain signals attract much
interest from the scientific and corporate communities. Good commercial prospects for …

Neuropathic pain, caused by a lesion or disease affecting the somatosensory system, affects
between 3 and 17% of the general population. The treatment of neuropathic pain is …