Cellular and molecular control of lipid metabolism in idiopathic pulmonary fibrosis: clinical application of the lysophosphatidic acid pathway
Y Nakamura, Y Shimizu - Cells, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a representative disease that causes fibrosis of the
lungs. Its pathogenesis is thought to be characterized by sustained injury to alveolar …
lungs. Its pathogenesis is thought to be characterized by sustained injury to alveolar …
Lipid mediators regulate pulmonary fibrosis: potential mechanisms and signaling pathways
V Suryadevara, R Ramchandran, DW Kamp… - International Journal of …, 2020 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease of unknown etiology
characterized by distorted distal lung architecture, inflammation, and fibrosis. The molecular …
characterized by distorted distal lung architecture, inflammation, and fibrosis. The molecular …
Bioactive lipid lysophosphatidic acid species are associated with disease progression in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with significant mortality.
Prognostic biomarkers to identify rapid progressors are urgently needed to improve patient …
Prognostic biomarkers to identify rapid progressors are urgently needed to improve patient …
Re-Examining the Role of Pulmonary Lipids in the Pathogenesis of Pulmonary Fibrosis
M O'Callaghan, EJ Tarling, JP Bridges… - American Journal of …, 2024 - atsjournals.org
Pulmonary fibrosis (PF) can be idiopathic or driven by a specific insult or disease process.
Inflammation plays a role in the pathophysiology, the extent of which remains a longstanding …
Inflammation plays a role in the pathophysiology, the extent of which remains a longstanding …
Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis
SB Montesi, SK Mathai, LN Brenner… - BMC Pulmonary …, 2014 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal disease with no
effective medical therapies. Recent research has focused on identifying the biological …
effective medical therapies. Recent research has focused on identifying the biological …
Lipids-two sides of the same coin in lung fibrosis
A Mamazhakypov, RT Schermuly, L Schaefer… - Cellular signalling, 2019 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is characterized by progressive extracellular matrix
deposition in the lung parenchyma leading to the destruction of lung structure, respiratory …
deposition in the lung parenchyma leading to the destruction of lung structure, respiratory …
Autotaxin emerges as a therapeutic target for idiopathic pulmonary fibrosis: limiting fibrosis by limiting lysophosphatidic acid synthesis
AM Tager - American journal of respiratory cell and molecular …, 2012 - atsjournals.org
There has been great recent interest in the bioactive lipid mediator lysophosphatidic acid
(LPA) in the pathogenesis of fibrotic diseases, from both academic laboratories and …
(LPA) in the pathogenesis of fibrotic diseases, from both academic laboratories and …
Lysophosphatidic acid is an important mediator of fibroblast recruitment in IPF
I Scott - Thorax, 2008 - thorax.bmj.com
Lysophosphatidic acid (LPA) and its G protein-coupled receptor (LPA1) play key pathogenic
roles in idiopathic pulmonary fibrosis (IPF). Previous research has highlighted the …
roles in idiopathic pulmonary fibrosis (IPF). Previous research has highlighted the …
Lipid metabolism in idiopathic pulmonary fibrosis: From pathogenesis to therapy
R Chen, J Dai - Journal of Molecular Medicine, 2023 - Springer
Idiopathic pulmonary fibrosis (IPF) is a chronic irreversible interstitial lung disease
characterized by a progressive decline in lung function. The etiology of IPF is unknown …
characterized by a progressive decline in lung function. The etiology of IPF is unknown …
Fatty acid metabolism and idiopathic pulmonary fibrosis
J Geng, Y Liu, H Dai, C Wang - Frontiers in Physiology, 2022 - frontiersin.org
Fatty acid metabolism, including the de novo synthesis, uptake, oxidation, and derivation of
fatty acids, plays several important roles at cellular and organ levels. Recent studies have …
fatty acids, plays several important roles at cellular and organ levels. Recent studies have …