Dopamine-glutamate interplay dysfunctions have been suggested as pathophysiological
key determinants of major psychotic disorders, above all schizophrenia and mood disorders …

The physical and functional interactions between serotonin–glutamate and serotonin–
dopamine signaling have been suggested to be involved in psychosis pathophysiology and …

Dopamine and glutamate systems are both involved in cognitive, behavioral, and motor
processes. Dysfunction of dopamine–glutamate interplay has been suggested in several …

Among the medical disciplines, psychiatry has for a long time held a special position
separate from natural sciences. This may be rooted in the old philosophical problem of the …

Schizophrenia is a severe psychiatric illness affecting almost 25 million people worldwide
and is conceptualized as a disorder of synaptic plasticity and brain connectivity …

Introduction: In recent years, the concept of 'synaptopathy'has been extended from
neurodegenerative and neurological disorders to psychiatric diseases. According to this …

Dopaminergic, serotonergic and noradrenergic nuclei form the trimonoamine modulating
system (TMMS). This system modulates emotional/motivational activities mediated by the …

The dopamine system has been a subject of intense investigation due to its role in a number
of normal functions and its disruption in pathological conditions. Thus, the dopamine system …

The dopaminergic system integrated by cell groups distributed in several brain regions
exerts a modulatory role in brain. Particularly important for this task are the mesencephalic …

Aberrant synaptic plasticity, originating from abnormalities in dopamine and/or glutamate
transduction pathways, may contribute to the complex clinical manifestations of bipolar …