Since the discovery of the amyloid precursor protein (APP) in 1987, extensive research has
been conducted analyzing the APP-derived β-amyloid (Aβ) which is found in massive …

J. Neurochem.(2012) 120 (Suppl. 1), 109–124. Abstract The amyloid‐β precursor protein
(βAPP) undergoes several cleavages by enzymatic activities called secretases. Numerous …

Alzheimer's disease (AD) is a neurodegenerative disorder that represents the most common
type of dementia in the elderly. One of the hallmarks of this disease is a progressive …

Altered proteolytic processing of the β-amyloid precursor protein (APP) is a central event in
familial and sporadic Alzheimer's disease (AD). In a process termed regulated …

Amyloid precursor protein (APP)-derived intracellular domain (AICD) has a cytotoxic effect
on neuronal cells and also participates in the regulation of gene transactivation. However …

Amyloidogenic processing of the amyloid precursor protein (APP) results in the generation
of β-amyloid, the main constituent of Alzheimer plaques, and the APP intracellular domain …

For 20 years the amyloid cascade hypothesis of Alzheimer disease (AD) has placed the
amyloid-β peptide (Aβ), formed from the amyloid precursor protein (APP), centre stage in the …

The amyloid precursor protein (APP) metabolism is central to pathogenesis of Alzheimer's
disease (AD). Parenchymal amyloid deposits, a neuropathological hallmark of AD, are …

One of the major pathological hallmarks of brains affected with Alzheimer's disease (AD) is
the senile plaque, an extracellular deposit mainly composed of a set of highly insoluble …

Alzheimer's disease (AD) is the most common neurodegenerative disease with tens of
millions of people affected worldwide. The pathogenesis is still poorly understood and …