Abstract http://creativecommons. org/licenses/by/2.5/-----Since the discovery of the TCF/LEF
family of transcription factors, their functions have been under intensive investigation in the …

Astrocytomas are the most common form of primary brain tumors. Understanding the
molecular basis of development and progression of astrocytomas is required to develop …

Background: Aberrant activation of the canonical Wingless-type MMTV integration site family
(WNT)/β-catenin signaling pathway is critical for gliomas. Materials and Methods: In 74 …

Abstract Transcription factor 4 (TCF4) is a member of the T-cell factor/lymphoid enhancer
factor (TCF/LEF) transcription factor family in the Wnt/β‑catenin signaling pathway. The …

The expression patterns of critical molecular components of Wnt signaling, sFRP3 and
DVL3, were investigated in glioblastoma, the most aggressive form of primary brain tumors …

Tcf family transcription factors are the downstream effectors of the Wnt signal transduction
pathway that regulates developmental and oncogenetic processes among species. The …

Glioblastoma (GBM) is a highly heterogeneous and aggressive brain tumor. Comprehensive
genomic and transcriptomic analyses revealed that GBM segregates into three subgroups …

Wnt signaling has been identified as a critical regulator of human tumor development in
vitro. However, there remains a lack of studies systematically examining the expression …

Gliomas are the most common primary intracranial tumors. Understanding the molecular
basis of gliomas' progression is required to develop more effective therapies. The Wnt/β …

Objective: The human T cell transcription factor-4 (TCF4) interacts functionally with β-catenin
in the Wnt signaling pathway, whose deregulation is involved in the tumorigenesis of various …