Non-coding RNAs in human disease

M Esteller - Nature reviews genetics, 2011 - nature.com
The relevance of the non-coding genome to human disease has mainly been studied in the
context of the widespread disruption of microRNA (miRNA) expression and function that is …

The implications of ncRNAs in the development of human diseases

E López-Jiménez, E Andrés-León - Non-coding RNA, 2021 - mdpi.com
The mammalian genome comprehends a small minority of genes that encode for proteins
(barely 2% of the total genome in humans) and an immense majority of genes that are …

Non-coding RNAs as mediators of epigenetic changes in malignancies

S Kumar, EA Gonzalez, P Rameshwar, JP Etchegaray - Cancers, 2020 - mdpi.com
Simple Summary This review discusses the role of non-coding RNAs (ncRNAs) in cancer
epigenetics, mostly focusing on how deregulated microRNAs (miRNAs) and long non …

Non-coding RNAs: a key to future personalized molecular therapy?

M Galasso, M Elena Sana, S Volinia - Genome medicine, 2010 - Springer
Continual discoveries on non-coding RNA (ncRNA) have changed the landscape of human
genetics and molecular biology. Over the past ten years it has become clear that ncRNAs …

Noncoding RNA s in disease

E Lekka, J Hall - FEBS letters, 2018 - Wiley Online Library
Noncoding RNA s are emerging as potent and multifunctional regulators in all biological
processes. In parallel, a rapidly growing number of studies has unravelled associations …

Non‐coding RNAs: regulators of disease

RJ Taft, KC Pang, TR Mercer, M Dinger… - The Journal of …, 2010 - Wiley Online Library
For 50 years the term 'gene'has been synonymous with regions of the genome encoding
mRNAs that are translated into protein. However, recent genome‐wide studies have shown …

[HTML][HTML] Non-coding RNAs: multi-tasking molecules in the cell

AQ Gomes, S Nolasco, H Soares - International journal of molecular …, 2013 - mdpi.com
In the last years it has become increasingly clear that the mammalian transcriptome is highly
complex and includes a large number of small non-coding RNAs (sncRNAs) and long …

Gene regulation by non-coding RNAs

VS Patil, R Zhou, TM Rana - Critical reviews in biochemistry and …, 2014 - Taylor & Francis
The past two decades have seen an explosion in research on non-coding RNAs and their
physiological and pathological functions. Several classes of small (20–30 nucleotides) and …

Non-coding RNAs in human cancer and other diseases: overview of the diagnostic potential

R Beňačka, D Szabóová, Z Guľašová… - International journal of …, 2023 - mdpi.com
Non-coding RNAs (ncRNAs) are abundant single-stranded RNA molecules in human cells,
involved in various cellular processes ranging from DNA replication and mRNA translation …

Crosstalk between long noncoding RNAs and microRNAs in health and disease

AS Bayoumi, A Sayed, Z Broskova, JP Teoh… - International journal of …, 2016 - mdpi.com
Protein-coding genes account for only a small part of the human genome; in fact, the vast
majority of transcripts are comprised of non-coding RNAs (ncRNAs) including long ncRNAs …