The power of cation-initiated cyclizations of polyenes for the synthesis of polycyclic
terpenoids cannot be overstated. However, a major limitation is the intolerance of many …

A novel CoII‐catalyzed polyene cyclization was developed that is uniquely effective when
performed in hexafluoroisopropanol as the solvent. The process is presumably initiated by …

We describe a new strategy to control the number of cyclization steps in bioinspired radical
(poly) cyclizations involving epoxypolyenes containing keto units positioned along the …

Covering: 2011–2017 Radical cyclizations have a rich history in organic chemistry and have
been particularly generous to the field of natural product synthesis. Owing to their ability to …

This tutorial review highlights the development of radical-based bioinspired synthesis of
terpenes from the initial proposal to the development of modern catalytic methods for …

A new polyene cyclization strategy exploiting β-ionyl derivatives was developed.
Photoinduced deconjugation of the extended π-system within these chromophores unveils a …

The biosynthesis of cyclic terpenes from polyene precursors by cyclase enzymes is one of
nature's most elegant chemical transformations.[1] The ease with which nature creates …

Meroterpenoids are natural products of hybrid biosynthetic origins—derived from both
terpenoid and polyketide pathways—with a wealth of biological activities. Given their …

Cascade radical transformations of acyclic precursors open efficient, convenient and atom‐
economical access to functionalized compounds of increased structural complexity. This …

A divergent strategy for assembling pyrone diterpenes is presented. Capitalizing on the
unique stereo-and chemoselectivity features of radical-based chemistry, the core decalin of …