Gβγ subunit inhibitor decreases DOM-induced head twitch response via the PLCβ/IP3/Ca2+/ERK and cAMP signaling pathways
H Zhu, X Liu, X Wang, Y Li, F Ma, B Tan, P Zhou… - European Journal of …, 2023 - Elsevier
Abstract Aims (−)-2, 5-dimethoxy-4-methylamphetamine (DOM) induces the head-twitch
response (HTR) primarily by activating the serotonin 5-hydroxytryptamine 2A receptor (5-HT …
response (HTR) primarily by activating the serotonin 5-hydroxytryptamine 2A receptor (5-HT …
Modulation of DOM-Induced Head-Twitch Response by mGluR2 Agonist/Inverse Agonist is Associated with 5-HT2AR-Mediated Gs Signaling Pathway
H Gao, X Liu, L Xie, B Tan, R Su - Neurochemical Research, 2024 - Springer
Abstract Hallucinogenic 5-HT2A receptor (5-HT2AR) agonists-induced head-twitch
response (HTR) is regulated by Gs signaling pathway. Formation of heterodimers between 5 …
response (HTR) is regulated by Gs signaling pathway. Formation of heterodimers between 5 …
Gs signaling pathway distinguishes hallucinogenic and nonhallucinogenic 5-HT2AR agonists induced head twitch response in mice
X Liu, H Zhu, H Gao, X Tian, B Tan, R Su - Biochemical and Biophysical …, 2022 - Elsevier
HT 2A receptor is a member of the family A G-protein-coupled receptor. It is involved in many
psychiatric disorders, such as depression, addiction and Parkinson's disease. 5-HT 2A R …
psychiatric disorders, such as depression, addiction and Parkinson's disease. 5-HT 2A R …
5-hydroxytryptamine 2C/1A receptors modulate the biphasic dose response of the head twitch response and locomotor activity induced by DOM in mice
H Zhu, L Wang, X Wang, Y Yao, P Zhou, R Su - Psychopharmacology, 2024 - Springer
Abstract Rationale The phenylalkylamine hallucinogen (-)-2, 5-dimethoxy-4-
methylamphetamine (DOM) exhibits an inverted U-shaped dose-response curve for both …
methylamphetamine (DOM) exhibits an inverted U-shaped dose-response curve for both …
[HTML][HTML] Metabotropic Glutamate2 Receptors Play a Key Role in Modulating Head Twitches Induced by a Serotonergic Hallucinogen in Mice
MJ Benvenga, SF Chaney, M Baez… - Frontiers in …, 2018 - frontiersin.org
There is substantial evidence that glutamate can modulate the effects of 5-
hydroxytryptamine2A (5-HT2A) receptor activation through stimulation of metabotropic …
hydroxytryptamine2A (5-HT2A) receptor activation through stimulation of metabotropic …
Anandamide inhibits the DOI-induced head-twitch response in mice
N Egashira, K Mishima, T Uchida, N Hasebe… - …, 2004 - Springer
Abstract Rationale Recently, Δ 9-tetrahydrocannabinol (THC), the major psychoactive
component of marijuana, and synthetic cannabinoid receptor agonists reportedly reduced …
component of marijuana, and synthetic cannabinoid receptor agonists reportedly reduced …
Support for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2, 5-dimethoxy-4-iodoamphetamine …
CE Canal, RG Booth, D Morgan - Neuropharmacology, 2013 - Elsevier
There are seemingly conflicting data in the literature regarding the role of serotonin (5-HT) 5-
HT2C receptors in the mouse head-twitch response (HTR) elicited by the hallucinogenic 5 …
HT2C receptors in the mouse head-twitch response (HTR) elicited by the hallucinogenic 5 …
Chronic treatment with a metabotropic mGlu2/3 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen
AL Halberstadt, JVF van der Zee, M Chatha… - …, 2019 - Springer
Background There is evidence that mGlu2/3 receptors regulate 5-HT 2A signaling,
interactions that have been theorized to play a role in the antipsychotic-like effects of …
interactions that have been theorized to play a role in the antipsychotic-like effects of …
Pharmacological modulation of abnormal involuntary DOI-induced head twitch response in male DBA/2J mice: I. Effects of D2/D3 and D2 dopamine receptor selective …
C Rangel-Barajas, M Malik, S Vangveravong… - …, 2014 - Elsevier
Because of the complexity and heterogeneity of human neuropsychiatric disorders, it has
been difficult to identify animal models that mimic the symptoms of these neuropathologies …
been difficult to identify animal models that mimic the symptoms of these neuropathologies …
Inhibition of 5-HT2 receptor-mediated head-twitch response by cocaine via indirect stimulation of adrenergic α2 and serotonergic 5-HT1A receptors
NA Darmani, BR Martin, U Pandey… - … Biochemistry and Behavior, 1991 - Elsevier
Abstract Cocaine inhibits the 5-HT 2-mediated (±)-DOI-induced head-twitch response (HTR)
in mice in a dose-dependent manner. In order to investigate the possible inhibitory …
in mice in a dose-dependent manner. In order to investigate the possible inhibitory …